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EC number: 240-005-7 | CAS number: 15876-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The supporting QMRF report has been attached
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Principles of method if other than guideline:
- Prediction is done using OECD QSAR Toolbox version 3.4 with logKow as the primary descriptor.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Di aluminium tris [2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate]
- Molecular formula :C20H8Br4O5.2/3Al
- Molecular weight :1991.5992 g/mol
- InChl :1S/3C20H8Br4O5.2Al/c3*21-11-5-9-17(13(23)15(11)25)28-18-10(6-12(22)16(26)14(18)24)20(9)8-4-2-1-3-7(8)19(27)29-20;;/h3*1-6,25-26H;;/q;;;2*+3/p-6
- Substance type:Organic
- Physical state:Solid - Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Microorganisms
- Duration of test (contact time):
- 28 d
- Parameter followed for biodegradation estimation:
- other: BOD
- Key result
- Parameter:
- other: BOD
- Value:
- 6.4
- Sampling time:
- 28 d
- Remarks on result:
- other: Other details not known.
- Details on results:
- Test substance Di aluminium tris [2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate] undegoes 6.4% degradation by BOD parameter in 28 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The test chemical Dialuminium tris(2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate) was estimated to be not readily biodegradable in water.
- Executive summary:
Biodegradability of Dialuminium tris(2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate) is predicted using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor (2017). Test substance undegoes 6.4% degradation by BOD parameter and microrganisms as inoculum in 28 days.The test chemical Di aluminium tris [2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate] was estimated to be not readily biodegradable in water.
Reference
The
prediction was based on dataset comprised from the following
descriptors: BOD
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((("a"
or "b" or "c" )
and "d" )
and ("e"
and (
not "f")
)
)
and ("g"
and (
not "h")
)
)
and ("i"
and "j" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Phenolphthaleins AND Phenols
(Acute toxicity) AND Phenols (Chronic toxicity) by US-EPA New Chemical
Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Phenols (Chronic toxicity) by
US-EPA New Chemical Categories
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as AN2 AND AN2 >> Michael-type
addition to quinoid structures AND AN2 >> Michael-type addition to
quinoid structures >> Substituted Phenols by Protein binding by OASIS
v1.4
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Does NOT Biodegrade Fast by
Biodeg probability (Biowin 2) ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Non binder, MW>500 by Estrogen
Receptor Binding
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Moderate binder, OH grooup OR
Non binder, impaired OH or NH2 group OR Strong binder, OH group OR Very
strong binder, OH group OR Weak binder, OH group by Estrogen Receptor
Binding
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Halogens AND Non-Metals by
Groups of elements
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Alkali Earth by Groups of
elements
Domain
logical expression index: "i"
Parametric
boundary:The
target chemical should have a value of Molecular weight which is >= 531
Da
Domain
logical expression index: "j"
Parametric
boundary:The
target chemical should have a value of Molecular weight which is <= 784
Da
Description of key information
Biodegradability of Dialuminium tris(2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate) is predicted using QSAR toolbox version 3.4 with log Kow as the primary descriptor (2017). Test substance undegoes 6.4% degradation by BOD in 28 days.The test chemical Dialuminium tris(2 -(2,4,5,7 -tetrabromo-6 -oxido-3 -oxoxanthen-9 -yl)benzoate) was estimated to be not readily biodegradable in water.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The predicted data for the target and various study of its read across substance were reviewed for the biodegradation end point which are summarized as below:
Biodegradability of target chemical Dialuminium tris(2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate) (CAS no. 15876 -39 -8) is predicted using QSAR toolbox version 3.4 with logKow as the primary descriptor (2017). Test substance undegoes 6.4% degradation by BOD in 28 days.The test chemical Dialuminium tris(2 -(2,4,5,7 -tetrabromo-6 -oxido-3 -oxoxanthen-9 -yl)benzoate) was estimated to be not readily biodegradable in water.
In a weight of evidence study from peer reviewed journal (U. Pagga and O. Brown, 1986), aerobic degradation of Eosim (CAS no. 17372 -87 -1) was studied (U. Pagga and O. Brown, 1986) by a modification of the OECD Guideline 302B used as the static test method. The main variations from the OECD method were the extension of the test period from 28 to 42 days and, because the test time was relatively long, the weekly feeding of the sludge by most of the participating laboratories. The sources of the activated sludge were treatment plants conveniently located to the laboratories carrying out the test. Each week 100 mg/l of yeast extract was used for the feeding of the test inoculum. Conc. of the test chemical and inoculum used for the study was 100 mg/l and 0.5g/l, respectively. Detection method involve the determination of extinction at absorption maximum of 412 nm and DOC (dissolved organic carbon). The DOC elimination of the test chemical was found to be -3% after 42 days. Based on the criteria for evaluation of the static test results, Acid red 87 was in Category D, which signifies that the test chemical was found to not readily biodegradable in nature at the end of 42 days.
For the same read across chemical Eosin (CAS no. 17372 -87 -1), Degradation of test chemical Eosin was studied (Laura Carmen Apostol et. al; 2012) using non-acclimated anaerobic granular sludge under anaerobic conditions. Non-acclimated anaerobic granular sludge was collected from wastewater treatment plant of ‘‘Central de Cervejas’’, Vialonga, Portugal. The volatile suspended solids content of the biomass was determined as 0.0943 g VSS g-1. Eosin Y was screened for biodegradation using an anaerobic granular biomass. The biomass, 0.94g/l VSS (Volatile suspended solids), the substrate and macronutrients in a total volume of 50 ml of medium, that was buffered at a pH of 7 ± 0.2 with NaHCO3(2.5 g L-1). As macronutrients, 2.8 g/L NH4Cl, 2.5 g/L; KH2PO4, 1 g/L MgSO4.7H2O and 0.06 g/L CaCl2were added. Volatile fatty acids (VFAs: acetic, propionic, and butyric acid, 1:10:10) were supplemented as electron source for the reduction (2 g COD L-1). After the pre-incubation period, the dye was added with a syringe from the stock solution to a final concentration of 0.3mM. After the pre-incubation period, the dye was added with a syringe from the stock solution to a final concentration of 0.3 mM. The serum bottles were further incubated at 37°C in a rotary shaker at 120 rpm, for 1 day. All the experiments were prepared in triplicate. For the anaerobic biological dye degradation, batch assays were performed in the same conditions as the dye degradation assay. The effect of biomass concentration on decolorization was evaluated. Biomass concentrations (0.94, 1.89, 3.77, and 4.71 g/l VSS) were assayed. Color decrease was monitored spectrophotometricaly in a 96-well plate reader . Compounds were eluted at a flow rate of 0.7 ml/ min and at room temperature, with a linear gradient of mobile phase from 10 to 100 % of solvent A, over 15 min, followed by isocratic condition with 100 % of solvent A over 10 min. Compounds elution was monitored at λmax of the dye and 230 nm. Samples were withdrawn (300 µL), at select intervals, samples were centrifuged at 5000 rpm for 10 min to remove the biomass and diluted, with the same buffer as of the reaction, to obtain less than one absorbance unit (AU), due to the high absorbance of the dye, even at low concentrations biomass. The decolorization (%) of Eosin B was merely 7% in the screening assay.
In a weight of evidence of another read across chemical Phoxine B (CAS no. 18472 -87 -2), the biodegradability of phloxine B was studied (Yasuhide TONOGAI et. al; 1978) using methods: Aerobic degradability, Warburg method and BOD measurement. Return activated sludge was obtained from the municipal sewage treatment plant, Nakahama, Osaka. Synthetic sewage preparation: Glucose peptone and potassium dihydrogen phosphate, 30g each, were dissolved in 1 liter water and the pH was adjusted to pH 7.0 with sodium hydroxide. Seeded Dilution water: To 1 liter, 10 ml of supernatant of sludge was added. Aerobic biodegradation assay: To 750ml of sludge (MLSS ca, 3,000 ppm) 250 ml of O.03 M dye solution was added, and bubbled with air sufficiently at 20°C. 5ml sample was taken out once a day. After sampling 5ml of synthetic sewage was added to the mixture. Each sample was filtered through filter paper and diluted twenty times prior to the spectrophotometric measurement at the absorption maximum within the visible range. The decrease of dyes concentration was expressed in terms of percent to the initial absorption. The experiment was carried out for 10 days. Oxygen uptake of sludge [Warburg Method]- 2.0 ml of sludge, 0.2 ml of 1000 ppm dye solution, and 0.2 ml of 20% potassium hydroxide were pipetted into the vessel, the side arm and central well, respectively. The sludge and the dye solution were mixed and the vessel was shaken at 25°C. The oxygen uptake was measured. The oxygen uptake by sludge alone was subtracted from those by dyes addition.
Determination of BOD – Dye solution (10, 20, and 40 ppm) were prepared with the seeded dilution water and kept at 20°C (Japanese Industrial Standards Committee, 1971). The dissolved oxygen contents were measured by a dissolved oxygen meter, because of the coloration of the solutions.As there is no regulation on the color of the effluent by the Water Pollution Control Law, discharge of coloring materials is regulated by only BOD or COD. The COD, BOD and absorbance at 245 and 545 nm (representing ultraviolet and the visible absorbance) of Phloxine B was studied. During 10 days of the aerobic experiment, the absorbance of dye solution was measured once day for 10 days. Food Red No. 104 was scarcely decreased. Free acids of Red No.104, was precipitated due to the slight acidity (pH 6-7) of the solution. Based on the results obtained from the studies, it can be concluded that Phloxine B is not readily biodegradable under aerobic conditions. Phloxine B was found to be non- biodegradable in the anaerobic test also performed.
On the basis of above results of various study for test chemical and for its read across substance, it can be concluded that the test substance
Dialuminium tris(2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate) is not expected to be readily biodegradable in nature.
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