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EC number: 269-941-4 | CAS number: 68391-30-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- OPINION ON Basic Red 76
- Author:
- Scientific Committee on Consumer Safety SCCS
- Year:
- 2 011
- Bibliographic source:
- Scientific Committee on Consumer Safety SCCS - adopted at its 10th plenary meeting of 22 March 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- [7-hydroxy-8-[(2-methoxyphenyl)azo]-2-naphthyl]trimethylammonium chloride
- EC Number:
- 269-941-4
- EC Name:
- [7-hydroxy-8-[(2-methoxyphenyl)azo]-2-naphthyl]trimethylammonium chloride
- Cas Number:
- 68391-30-0
- Molecular formula:
- C20H22ClN3O2
- IUPAC Name:
- 7-hydroxy-8-[(2-methoxyphenyl)diazenyl]-N,N,N-trimethylnaphthalen-2-aminium chloride
- Reference substance name:
- Basic Red 76
- IUPAC Name:
- Basic Red 76
- Details on test material:
- - Name of test material (as cited in study report):Basic Red 76- Molecular formula (if other than submission substance):C20H22N3O2 Cl- Molecular weight (if other than submission substance):371.86g/mol- Substance type:Organic- Physical state:SolidPurityDetermined by HPLC = 98.1 % (AUC, HPLC), - Impurities (identity and concentrations):water content = 5.1%(w/w); Monomethyl sulphate 11.8% (w/w); o-anisidine = 5ppm; Sulphated ash 0.4% (w/w); Chloride 1.6% (w/w); Sodium = 630 ppm; Calcium = 590 ppm; Saccharose = 25.8%(w/w)
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALSAge at study initiation: Adult New Zealand White albino male rabbits
Test system
- Vehicle:
- not specified
- Controls:
- yes
- Amount / concentration applied:
- 100 mg of test substance
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 72 hours to 7 days
- Number of animals or in vitro replicates:
- 3 rabbits – 1 male and 2 females
- Details on study design:
- TEST SITEArea of exposure: conjuctival sac of the left eye% coverage:Type of wrap if used:REMOVAL OF TEST SUBSTANCEWashing (if done): The substance remained in permanent contact with the eyes until rinsing with warm tap waterTime after start of exposure: 24 hours after instillation.SCORING SYSTEM: The eye irritation reactions were scored approximately 1, 24, 48 and 72 hours and 7 days after instillation of the test solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: upto 72 hrs
- Reversibility:
- fully reversible within: 72 hrs
- Remarks on result:
- other: mild, early-onset and transient ocular changes, such as reddening of the conjunctivae and sclerae, discharge and chemosis.
- Irritant / corrosive response data:
- Slight red staining of the treated eyes by the test item was observed in all animals at the 1- and 24- hour reading and persisted in two animals up to 48 hours and in one animal up to 72 hours after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Eye irritation study was carried out on New Zealand White rabbits according to OECD 405 Guidelines to determine the irritation potency of Basic Red 76.The instillation of the undiluted Basic Red 76 into the eyes resulted in mild, early-onset and transient ocular changes, such as reddening of the conjunctivae and sclerae, discharge and chemosis.These effects were reversible and were no longer evident 72 hours after treatment. No abnormal findings were observed in the cornea or iris of any animal at any of the examinations. No corrosion was observed at any of the measuring intervals. Slight red staining of the treated eyes by the test item was observed in all animals at the 1- and 24- hour reading and persisted in two animals up to 48 hours and in one animal up to 72 hours after treatment. The study was terminated seven days after instillation.Under the conditions of the study, Basic Red 76 was considered to be not irritating to rabbit eyes.
- Executive summary:
Eye irritation study was carried out on New Zealand White rabbits according to OECD 405 Guidelines to determine the irritation potency of Basic Red 76.
100 mg of Basic Red 76 was instilled into the conjunctival sac of the left eye of the test animals. The substance remained in permanent contact with the eyes until rinsing with warm tap water, 24 hours after instillation. The right eyes served as controls. The eye irritation reactions were scored approximately 1, 24, 48 and 72 hours and 7 days after instillation of the test solution.
The instillation of the undiluted Basic Red 76 into the eyes resulted in mild, early-onset and transient ocular changes, such as reddening of the conjunctivae and sclerae, discharge and chemosis.
These effects were reversible and were no longer evident 72 hours after treatment. No abnormal findings were observed in the cornea or iris of any animal at any of the examinations. No corrosion was observed at any of the measuring intervals. Slight red staining of the treated eyes by the test item was observed in all animals at the 1- and 24- hour reading and persisted in two animals up to 48 hours and in one animal up to 72 hours after treatment. The study was terminated seven days after instillation.
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