Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-562-7 | CAS number: 108-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-09-30 to 2000-06-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Isopropenyl acetate
- EC Number:
- 203-562-7
- EC Name:
- Isopropenyl acetate
- Cas Number:
- 108-22-5
- Molecular formula:
- C5H8O2
- IUPAC Name:
- isopropenyl acetate
- Details on test material:
- Test Substance: 2-Acetoxypropene (Essigsaureisopropenylester)
Date of production: unknown
Physical state / appearance: liquid / colourless
Storage conditions: room temperature
CAS No.: 108-22-5
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female Wistar rats (strain: Rj : WI (SPF Han)) supplied by Elevage Janvier, Route des Chenes Secs, B.P. 5, F-53940 Le Genest St Isle were used for the investigations. Only animals free from clinical signs of disease were used for the study. The females were nulliparous and non-pregnant. The animals were subjected to an acclimatization period of at least 1 week in which they were adapted to the surroundings. Age of the animals at the beginning of the study was approx. 8 - 9 weeks. Weight: Males 309.92 +/- 5.11 g, Females 207.00 +/- 3.88 g.
The animals were offered KLIBA rat/mouse/hamster laboratory diet 10 mm pellets, Provimi
Kliba SA, Kaiseraugst, Switzerland, and drinking water ad libitum during the post-exposure
observation period.
The feed used in the study was assayed for chemical as well as for microbiological contaminants.
In view of the aim and duration of the study, the contaminants occurring in
commercial feed might not influence the results.
The drinking water is regularly assayed for chemical contaminants by the municipal authorities of Frankenthal and the Technical SeNices of BASF -Aktiengesellschaft as well as for the presence of germs by a contract laboratory. In view of the aim and duration of the study, there are no special requirements exceeding the specification of drinking water. The animals were kept in fully air-conditioned rooms in which temperatures in the range of 20 - 24°C and relative humidities in the range of 30 - 70°J!c> were regulated by means of a central air-conditioning system.
They were housed singly in cages type DK III (Seeker, Germany) without bedding, with a light/dark cycle of 12 hours (6 a.m. - 6 p.m. light on, 6 p.m. - 6 a.m. light off).
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Whole-body inhalation system: IKA 02 (glass-steel construction), BASF Aktiengesellschaft, volume V ~ 200 I: the animals were kept singly in compartmentalized wire cages, and were exposed in the chamber. The homogenous distribution of atmospheres in this inhalation system has been proven in technical tests with model vapors.
Technical equipment
• piston metering pump KP 2000 (Desaga)
• vaporizer with thermostat (glass, BASF)
• glass mixing stage (BASF) - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gas Chromatography
- Duration of exposure:
- 4
- Concentrations:
- 22 mg/l
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- The vapor was generated by supplying amounts of the test substance to the heated vaporizer by means of the piston metering pump. The vapors that developed were taken up by the supply air and passed into the exposure system.
The exposure system was located inside an exhaust cabin in an air-conditioned laboratory. A supply air flow (conditioned air (from a central air-conditioning system)) of 3.0 m3/h was used for the test group. The exhaust air flow was 3.3 m3/h. An air change of about 15 times per hour can be calculated by dividing the supply air flow by the volume of the inhalation system. The higher amount of exhaust air, which was adjusted by means of a separate exhaust air system, achieved a negativ pressure inside the exposure system. This ensured that no contamination of the laboratory occurred as result of possible leakage from the inhalation chamber. The animals were exposed to the inhalation atmosphere for 4 hours plus equilibration time of the inhalation systems (tgg about 20 min ). - Statistics:
- The statistical evaluation of the concentration-response relationship was carried out using a computer program: Depending on the data of the concentration-response relationship obtained by way of experiment, this program is used to estimate the LC50 or to perform a Probit analysis (4). Estimation of the LC50 will produce types "LC50 greater than", "LC50 approx.", or "LC50 smaller than". If the results are type "LC50 greater than" or "LC50 smaller than", an additional binomial test is carried out (5), in order to verify these statements statistically.
Results and discussion
- Preliminary study:
- not reported
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 22 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: none
- Mortality:
- not observed in the dose groups
- Clinical signs:
- other: eyelid closure, visually accelerated respiration, nasal discharge and crust formation as well as apathy, squatting posture, reduced general state, smeared fur and piloerection
- Body weight:
- no effect
- Gross pathology:
- no effect
- Other findings:
- not reported
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance is not harmful to rats under conditions used after vapor inhalation.
- Executive summary:
For determination of the acute inhalation toxicity (single 4-hour-exposure) of 2-Acetoxypropene (Isopropenyl acetate, Essigsäureisopropenylester) as a vapor, a study in male and female Wistar rats was performed according to OECD-Guideline method 403, as well as EEC and EPA guidelines. No mortality occurred at the analytically determined concentration of 22 mg/l (Limit test). The LC50 for male and female animals (5 animals/group) therefore is > 22 mg/l (> 5300 ppm). Clinical examination reveal edeyelid closure, visually accelerated respiration, nasal discharge and crust formation as well as apathy, squatting posture, reduced general state, smeared fur and piloerection . No clinical signs could be detected from post exposure day 7 onward. Body weight development of the male animals was slightly depressed in the first post exposure week but recovered in the second. The female animals did not gain weight throughout the post exposure observation period. During necropsy no macroscopic pathologic findings were noted in the animals examined at the end of the study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.