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Diss Factsheets
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EC number: 931-468-2 | CAS number: 1190625-94-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The registration substance, and all major relevant components thereof, are considered unlikely to be persistent.
While under strict conditions of OECD 301B no degradation occurred, substance properties may have confounded assessment in this study.
Relevant components have been reliably assessed in QSAR models and are predicted to undergo rapid degradation, hence weight of evidence conclusion is some inherent degradation potential for registration substance.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable, not fulfilling specific criteria
Additional information
In the experimental study, the potential of the test material to undergo biodegradation was investigated in a modified Sturm test conducted in accordance with the standardised guidelines OECD 301B, EU Method C.4-C, ISO 9439 and ISO 10634 under GLP conditions. The study was awarded a reliability score of 2 in accordance with the principles for assessing data quality set forth by Klimisch et al. (1997). Difficulties in the application and dispersion of the substance in the inoculum, despite use of inert carriers, mean that the overall result may not be a reliable indicator of degradation potential despite being conducted properly and to GLP.
Activated sludge from a municipal sewage treatment plant receiving predominantly domestic sewage was exposed to the test material for 28 days, with the last CO2 measurement on day 29. The test material was tested in duplicate at 14.5 mg/L, corresponding to 12 mg TOC/L. Based on the TOC content, the ThCO2 of the test material was calculated to be 3.04 mg CO2/mg. The test material was not sufficiently soluble in water and tended to float on the surface of the test medium. Therefore, the test material was coated on an inert carrier. For each replica, 10 mL Milli-RO water was added to approximately 29 mg test material. After vigorous vortex mixing the resulting suspensions were added to individual test bottles containing 10 g silica. 300 mL Milli-RO water was added to the coated silica and thorough mixing was applied for 15 minutes to ensure homogenous distribution of the test material. The final test media were made up to 2 litres by adding inoculated medium and Milli-RO water. The test solutions were continuously stirred during the test, to ensure optimal contact between the test material and the test organisms. however this contact cannot be confirmed. The relative biodegradation values calculated from the measurements performed during the test period revealed no significant biodegradation of the test material (6 % in both replicates).
As per ECHA requirements for multiconstituent substances or UVCBs, the major relevant components of the registration substance were also assessed via predictive software tools EPIWIN at >0.1%, and the chemistry of the components assessed falls within the applicability domain. Therefore the outputs are deemed reliable and are used alongside the test result for the registration substance in a weight of evidnece assessment. The majority of these components are seen to be likely to degrade and are not likely to be persistent. A summary of the outputs of the EPIWIN models for persistence and for bioaccumulation is attached to this and shows that where a component may demonstrate a potential for one property (mainly bioaccumulation, but in one instance possibly persistence), no component appears to demonstrate potential for both, which adds reassurance to the contention that the overall substance will not be P and B.
Based on a weight of evidence assessment, the registration substance is considered not to be persistent in the environment. We therefore conclude it to be not P or vP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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