Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 218-542-3 | CAS number: 2177-70-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Generally accepted calculation method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The physicochemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux was calculated using the principles defined in the Potts and Guy prediction model. (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663- 669)
- GLP compliance:
- no
Test material
- Reference substance name:
- Phenyl methacrylate
- EC Number:
- 218-542-3
- EC Name:
- Phenyl methacrylate
- Cas Number:
- 2177-70-0
- Molecular formula:
- C10H10O2
- IUPAC Name:
- phenyl 2-methylprop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): Phenyl methacrylate
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- not applicable; in silico modelling
Administration / exposure
- Type of coverage:
- other: not applicable; in silico modelling
- No. of animals per group:
- not applicable; in silico modelling
Results and discussion
- Absorption in different matrices:
- predicted flux: 4.843 µg/cm²/h; the relative dermal absorption is low
Any other information on results incl. tables
Based on a molecular weight of 162.19 g/mol and a log Kow of 2.49, the predicted flux of PHMA is 4.843 µg/cm²/h; the relative dermal absorption is low.
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of PHMA is predicted to be low; the predicted flux is 4.843 µg/cm²/h.
- Executive summary:
The dermal absorption (steady-state flux) of PHMA has been estimated by calculation using the principles defined in the Potts and Guy prediction model.
Based on a molecular weight of 162.19 g/mol and a log Kow of 2.49, the predicted flux of PHMA is 4.843 µg/cm²/h; the relative dermal absorption is low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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