Registration Dossier
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EC number: 500-288-2 | CAS number: 103213-20-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects observed up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Fatty acids, C18-unsatd, dimers, hydrogenated, diisopropyl esters (CAS 103213-20-3) to aquatic algae are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Fatty acids, C18-unsatd., dimers, 2-ethylhexyl esters (CAS 68334-05-4) was conducted. The target substance Fatty acids, C18-unsatd., dimers, hydrogenated diisopropyl esters (CAS 103213-20-3) is characterized by two/three dimerised fatty acid moieties (C18 unsaturated) esterified with the alcohol component isopropanol. The source substance Fatty acids, C18-unsatd., dimers, 2-ethylhexyl esters (CAS 68334-05-4) is characterized as a dimerised ester of two C18:1 fatty acids with 2-ethylhexanol. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The study with the read-across substance Fatty acids, C18-unsatd., dimers, 2-ethylhexyl esters (CAS 68334-05-4) was performed according to OECD 201 (GLP) and investigated the toxicity to freshwater algae (Swarbrick and Smyth, 2005). The green algae Selenastrum capricornutum was exposed for 72 h to a limit Water Accommodated Fraction (WAF) concentration of nominal 100 mg/L. No effects on algal growth was observed resulting in an EL50 (72 h) > 100 mg/L (nominal) The NOELR (72 h) ≥ 100 mg/L (nominal) was determined.
Based on the available results from a structurally related read-across substance (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Fatty acids, C18-unsatd, dimers, hydrogenated, diisopropyl esters (CAS 103213-20-3) will not have effects on aquatic algae up to the limit of water solubility.
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