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EC number: 943-242-0 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 201).
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity of Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance neopentyl glycol dioleate (CAS 42222-50-4) was conducted. The source substance is representative to evaluate the toxicity of Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers to aquatic algae. Both substances are structurally very similar. The target substance is characterized as a diester of neopentylglycol esterified with mainly C18 unsaturated fatty acids. The main constituent of the source substance is the neopentyl glycol dioleate containing additional constituents of higher molecular weight. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13.
One study is available on the toxicity of neopentylglycol dioleate (CAS 42222-50-4) to aquatic freshwater algae (Häner, 2006). The study was performed according to OECD 201 using Desmodesmus subspicatus. The test organism was exposed to the test substance in a static system for 72 h, at the nominal loading rate of 100 mg/L (Water Accommodated Fraction (WAF)). No significant effects on growth rate and biomass of algae was observed and the ErL50 (72 h) value was reported to be > 100 mg/L. The corresponding NOErLR (72 h) was reported to be ≥ 100 mg/L.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the target substance Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers will not exhibit effects to aquatic algae up to the limit of water solubility.
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