Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 413-370-7 | CAS number: 17351-75-6 RAPICURE CHVE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- GPMT test already available (conducted in 1991)
Test material
- Reference substance name:
- 1,4-bis[(vinyloxy)methyl]cyclohexane
- EC Number:
- 413-370-7
- EC Name:
- 1,4-bis[(vinyloxy)methyl]cyclohexane
- Cas Number:
- 17351-75-6
- Molecular formula:
- C12 H20 O2
- IUPAC Name:
- (1r,4r)-1,4-bis[(ethenyloxy)methyl]cyclohexane; (1s,4s)-1,4-bis[(ethenyloxy)methyl]cyclohexane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): RAPI-CURE CHVE
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Harlan Olac Ltd. (Bicester, Oxfordshire, England)
- Age at study initiation: ca. 4 weeks
- Weight at study initiation: 224-265 g
- Housing: groups of 5 in stainless steel cages
- Diet (e.g. ad libitum): ad libitum (certified diet)
- Water (e.g. ad libitum): ad libitum (analyzed by local water authiorities)
- Acclimation period: 11 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18°C (15-23 °C)
- Humidity (%): 55% (40-70%)
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 h
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- paraffin oil
- Concentration / amount:
- Induction:
Intradermal: 0.1 ml 30 % v/v RAPI Cure CHVE in paraffin oil
Dermal: 10 % Sodium lauryl sulphate on day 7 to make the skin more susceptible and 100 % Rapi-cure on day 8
Challenge: 100 % and 30 % v/v RAPI Cure CHVE in paraffin oil
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- paraffin oil
- Concentration / amount:
- Induction:
Intradermal: 0.1 ml 30 % v/v RAPI Cure CHVE in paraffin oil
Dermal: 10 % Sodium lauryl sulphate on day 7 to make the skin more susceptible and 100 % Rapi-cure on day 8
Challenge: 100 % and 30 % v/v RAPI Cure CHVE in paraffin oil
- No. of animals per dose:
- 20
- Details on study design:
- RANGE FINDING TESTS:
intra dermal
50, 30, 10, 5, 3 % Rapi-cure CHVE in Paraffin oil and
50, 30, 10, 5, 1 % Rapi-cure CHVE in paraffin oil + FCA
dermal
100 , 50, 30, 10 % Rapi-cure CHVE in Paraffin oil
MAIN STUDY
- Test groups: 20 animals
- Control group: 20 animals
A. INDUCTION EXPOSURE
Intradermal: 0.1 ml 30 % v/v RAPI Cure CHVE in paraffin oil + FCA
Dermal : 10 % Sodium lauryl sulphate on day 7 to make the skin more susceptible and 100 % Rapi-cure on day 8
B. CHALLENGE EXPOSURE
- Exposure period: 24 h 8 (occlusive)
- Site: flank
- Concentrations: 100 % an 30 % v/v in paraffin oil
- Evaluation (hr after challenge): 24 and 48 h - Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- It is not reported whether there are regular experiments with a positive control substance conducted in the testing facility to test the guinea pig strain for positive response and the study personal to be able to identify a positive response. Due to animal welfare there is usually no positive control for each experiment.
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 30%
- No. with + reactions:
- 19
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 30%. No with. + reactions: 19.0. Total no. in groups: 20.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 30%
- No. with + reactions:
- 10
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 30%. No with. + reactions: 10.0. Total no. in groups: 20.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 30%
- No. with + reactions:
- 10
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 30%. No with. + reactions: 10.0. Total no. in groups: 20.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 30%
- No. with + reactions:
- 7
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 30%. No with. + reactions: 7.0. Total no. in groups: 20.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 30%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 30%. No with. + reactions: 0.0. Total no. in groups: 20.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 30%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 30%. No with. + reactions: 0.0. Total no. in groups: 20.0.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Executive summary:
A Maggnusson & Kligman Maximization test was conducted accoording to GLP-requirements and OECD Guideline No. 406. 10 of 20 Dunking Hartley guinea pigs developed a contact dermatitis against 30 % RAPI-cure CHVE in paraffin oil in that test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)