Registration Dossier
Registration Dossier
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EC number: 606-753-7 | CAS number: 213967-55-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECE guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- (E)-5-benzyl-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-N-nitro-1,3,5-triazinan-2-imine
- EC Number:
- 606-753-7
- Cas Number:
- 213967-55-6
- Molecular formula:
- C15H18ClN6O2S
- IUPAC Name:
- (E)-5-benzyl-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-N-nitro-1,3,5-triazinan-2-imine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 male
3 female - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
Any other information on results incl. tables
A dose of 2,000 mg/kg body weight was tolerated by male and female rats without mortalities and without clinical signs.
There were no toxicological effects on body weights or on body weight development in males and females.
No gross pathologic changes were observed in animals sacrificed at the end of the study period.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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