Registration Dossier
Registration Dossier
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EC number: 807-880-2 | CAS number: 1125812-54-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- LD50 calculation derived from an in vitro cytotoxicity test using 3T3 cells
- Principles of method if other than guideline:
- Cytotoxicity is assessed by the neutral red uptake viability test, performed in a dose reponse format to determine the IC50. The LD50 is calculated from IC50 using a linear regression formula
- GLP compliance:
- not specified
- Test type:
- other: LD50 calculation derived from an in vitro cytotoxicity test
Test material
- Reference substance name:
- 2-[(4-acetylnaphthalen-1-yl)formamido]-N-(2,2,2-trifluoroethyl)acetamide
- EC Number:
- 807-880-2
- Cas Number:
- 1125812-54-5
- Molecular formula:
- C17H15F3N2O3
- IUPAC Name:
- 2-[(4-acetylnaphthalen-1-yl)formamido]-N-(2,2,2-trifluoroethyl)acetamide
Constituent 1
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 380 other: mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The calculated LD50 is equal to 1380 mg/kg. The LD50 is between 300 and 2000 mg/kg, the classification is therefore a category 4 regarding the acute toxicity.
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