Registration Dossier
Registration Dossier
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EC number: 422-310-9 | CAS number: 114772-53-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not declared
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was obtained through ECHA CHEM database, in accordance with the the 12 years rule. Available data contain scanty study details: the limited amount of information and the lack of the full study report do not allow a proper reliability assessment.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- EC 422-310-0 (identity was verified during the database consultation procedure)
- IUPAC Name:
- EC 422-310-0 (identity was verified during the database consultation procedure)
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Samlmonella typhimurium TA 98, TA 100, TA 102, TA 1535, TA 1537
- Metabolic activation system:
- S9 from rat liver induced by Aroclor 1254
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 50-750 mcg/plate
Concentration range in the main test (without metabolic activation): 50-750 mcg/plate - Vehicle / solvent:
- dimethylsulfoxyde
Results and discussion
Test results
- Species / strain:
- bacteria, other: Salmonella typhimurium TA 98, TA 100, TA 102, TA 1535, TA 1537
- Metabolic activation:
- with and without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- > 500 mcg/plate
- Additional information on results:
- Positive controls gave expected results.
- Remarks on result:
- other: other: main test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative without metabolic activation
negative with metabolic activation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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