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EC number: 943-043-9 | CAS number: 8015-91-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin: corrosive to skin (OECD TG 431 and OECD TG 439 )
Eye: serious eye damage (OECD TG 438; no prediction can be made, the classification based on skin results)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
OECD TG 439:
The skin irritation potential of Cinnamon bark oil was tested in accordance with OECDTG439. Undiluted Cinnamon bark oil was applied to the skin model for 42 minutes. After a 42-hour post-incubation period, determination of the cytotoxic (irritancy) effect was performed using MTT conversion measurements. Cinnamon bark oil was identified as a direct MTT reducer (2.0% viability of the NSMTT control) but did not cause colour interference. The mean corrected tissue viability obtained after 42 minutes treatment with Cinnamon bark oil compared to the negative control tissues was 0.3%. The positive control had a mean cell viability of 1.3% and the OD values of the negative control tissues were 0.969, 0.843 and 0.833. Furthermore, the standard deviation value of the percentage viability of three tissues treated identically was less than 18%, indicating that the test system functioned properly. Based on this result, the substance does need to be classified for skin irritation or skin corrosion.
OECD TG 431
The skin corrosion potential of Cinnamon bark oil was tested according to OECDTG431. A human three-dimensional epidermal model (EpiCS®) was exposed topically to 50 μL undiluted Cinnamon bark oil, distilled water (negative control), or Potassium hydroxide (positive control) for 3 minutes or 1 hour. Cinnamon bark oil was identified as a direct MTT reducer (1.8% viability of the NSMTT control) but did not cause colour interference. Skin corrosion is expressed as the remaining cell viability after exposure to the test item. Both the negative and the positive control were considered valid. The relative mean tissue viability obtained after the 3-minute and 1-hour treatments with Cinnamon bark oil compared to the negative control tissues was 69.9% and 3.7% respectively. Based on these results, Cinnamon bark oil needs to be classified for skin corrosion.
Eye irritation
To evaluate the eye hazard potential of Cinnamon bark oil an isolated chicken eye test was performed according to OECDTG438. 30 μL of the test item was applied to the cornea of each of 3 chicken enucleated eyes and after 10 seconds the corneas were rinsed with physiological saline. After the exposure, toxic effects were measured by qualitative assessment of opacity (0.7, ICE class II), fluorescein retention (1.3, ICE class II), and corneal swelling (7% ICE class II). Valid positive (3x ICE class IV) and negative (3x ICE class I) controls were included. According to the overall in vitro irritancy criteria, the ICE classes combined for the test item led to the result ‘no prediction can be made'. Therefore, the substance is not predicted as causing serious eye damage (Category 1) or as not classified for eye irritation/serious eye damage (No category).
Justification for classification or non-classification
Based on the in vitro test results the substance is corrosive to skin but no prediction could be made on irritating/corrosive to the eyes. However, according to Annex I of the CLP Regulation (1272/2008/EC) skin corrosive substances shall be considered as leading to serious damage to the eyes as wel. Therefore the substance needs to be classified for skin corrosion (Skin Cor. Cat.1/H314 ) and for serious eye damage (Eye Dam. Cat.1/H318).
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