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EC number: 212-774-9 | CAS number: 868-19-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28-30 April 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with the OECD 202 guideline and complied with the principles of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Strontium tartrate
- EC Number:
- 212-774-9
- EC Name:
- Strontium tartrate
- Cas Number:
- 868-19-9
- Molecular formula:
- C4H4O6Sr
- IUPAC Name:
- strontium(2+) 2,3-dihydroxybutanedioate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Strontium tartrate (anhydrous)
- Appearance: Off-white powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- 4.8 mL samples for possible analysis were taken from all test concentrations and the control at t=0 and t=48 hours and were stored in the freezer until analysis.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Preparation of test solutions started with the highest concentration (100 mg/L) applying 30 minutes of magnetic stirring to accelerate the dissolving of the test substance in the test medium. The lower test concentrations were prepared by subsequent dilutions of the stock in test medium. The final test solutions were all clear and colourless.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Dapnia magna
- Source: In-house laboratory culture with a known history, at least third generation, obtained by acyclical parthenogenesis under specified breeding conditions.
- Age at study initiation (mean and range, SD): young daphnids with an age of < 24 hours, from parental daphnids of more than two weeks old.
- Method of breeding: start of each batch with newborn daphnids, i.e. less than 3 days old, by placing about 250 of them into 5 litres of medium in an all-glass culture vessel. Renewal of the cultures: after 7 days of cultivation half of the medium twice a week.
- Feeding during test: no
ACCLIMATION
- Acclimation period: <24 hours
- Acclimation conditions (same as test or not): no, breeding medium is M7
- Type and amount of food: a suspension of fresh water algae
- Feeding frequency: daily
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Post exposure observation period:
- None
Test conditions
- Hardness:
- 180 mg/L expressed as CaCO3
- Test temperature:
- 18.7 - 19.4 ºC
- pH:
- 7.7-8.0
- Dissolved oxygen:
- 8.6-9.1 mg/L
- Salinity:
- Not applicable.
- Nominal and measured concentrations:
- Nominal: 0.10, 1.0, 10 and 100 mg/L
At 100 mg/L, the actual concentration was at the level of nominal (109%) at the start of the test and remained stable during the test (99% of initial). Consequently, the effects parameters were reported in terms of the analytically confirmed nominal concentration. - Details on test conditions:
- TEST SYSTEM
- Test vessel:100 mL, all-glass, fill volume 80 mL
- Aeration: None
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4 for the limit concentration, 2 for the remaining concentrations
- No. of vessels per control (replicates): 4
- Biomass loading rate: 5 per vessel containing 80 mL test solutionn
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Adjusted ISO medium
- Culture medium different from test medium: Culture medium had extra trace elements, macro nutrients and vitamins added as specified in Medium M7.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours per day, During the first 24 hours of the study the lights were not turned off during the night. Therefore, the light period was longer than 16 hours during the first 24 hours.
- Light intensity: not indicated
EFFECT PARAMETERS MEASURED: mobility at 24 and 48 hours ; pH and dissolved oxygen at the beginning and at the end of the test. Temperature continuously.
TEST CONCENTRATIONS
- Test concentrations: combined limit/range-finding test: 0.10, 1.0, 10 and 100 mg/L. - Reference substance (positive control):
- yes
- Remarks:
- Potassiumdichromate
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Nominal test concentrations were analytically confirmed.
- Details on results:
- No effects were observed in any of the groups tested.
- Results with reference substance (positive control):
- The 48h-EC50 was 0.32 mg/L with a 95% confidence interval between 0.29 and 0.37 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- 1. No effects were observed in the control. 2. The oxygen concentration at the end of the test was ≥3 mg/l in control and test vessels
- Conclusions:
- No effects were observed in any of the groups. The 48h-EC50 of the test substance to Daphnia magna is > 100 mg/L.
- Executive summary:
A 48-h acute toxicity study in Daphnia magna was performed with Sodium tartrate according to OECD 202 and in compliance with GLP principles. A combined range-finder/ limit test was carried out under static conditions. The nominal test concentrations wer 0.10, 1.0, 10 and 100 mg/L. Preparation of test solutions started with the highest concentration (100 mg/L) applying 30 minutes of magnetic stirring to accelerate the dissolving of the test substance in the test medium. The lower test concentrations were prepared by subsequent dilutions of the stock in test medium. The final test solutions were all clear and colourless. Samples were taken for analysis at t = 0 and 48 hours. Samples of the control and 100 mg/L group were analysed by an ICP-MS method. At 100 mg/L, the actual concentration was at the level of nominal (109%) at the start of the test and remained stable during the test (99% of initial). Consequently, the effects parameters were reported in terms of the analytically confirmed nominal concentration.
During the first 24 hours of the study the lights were not turned off during the night. Therefore, the light period was longer than 16 hours. The results show that the daphnids were not affected (no immobility observed). Furthermore, at the end of the test the test substance concentration remained at the initial concentration (99% of initial) indicating that the light period did not influence the test substance concentration.
No effects were observed in any of the groups. The 48h-EC50 of the test substance to Daphnia magna is > 100 mg/L
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