Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-003-2 | CAS number: 130-95-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study is not done according to OECD guideline, but it is a well documented study.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenicity testing of quinine with submammalian and mammalian systems.
- Author:
- Muenzner, R. and Renner, H.W.
- Year:
- 1 983
- Bibliographic source:
- Toxicology 26(2):173-8
Materials and methods
- Principles of method if other than guideline:
- For the in vivo mutagenicity tests Chinese hamsters (own breeding colony) were used. Animals were kept under standardized conventional conditions (air temperature 21 +- 1°C; relative humidity 55 +- 5%; 15 air changes/h; light/dark cycle of 12 h). Control groups and test group consisted of equal numbers of male and females in the adolescent age (8-13 weeks). In all tests bone marrow cells were used.sister chromatid exchange:The sister chromatid exchange test was performed with 5-bromo-deoxyuridine tablets which were implanted in the experimental animals (weighing 30 +- 2 g) as described by Allen et al, 1977: 50 mg-tablets/animal, 26-h BrdU and 2-h colchicine (Demecolcin I mg/kg) treatment time. Four animals/group were used and 50 metaphases/animal were evaluated. A single quinine treatment was given by stomach tube as aqueous solution (vol. 0.3 ml) 2 h after BrdU implantation.micronucleus test:The micronucleus test was performed in accordance with the standard procedure proposed by Schmid et al, 1973 but only a single administration of quinine was given. Thirty hours later the bone marrow cells were flushed out; 6 animals/group were used and 1000 polychromatic erythrocytes/animal were evaluated for micronuclei.chromosome aberration test:The chromosome aberration test was carried out using the conventional technique (Schwarzacher and Wolf, 1974). Quinine administration was done in the same way as indicated in the SCE test: 24-h quinine and 2-h colchicine treatment. Six animals/group were used and 300 metaphases/animal were scored for structural aberrations.
- GLP compliance:
- not specified
- Type of assay:
- other: sister chromatid exchange test, micronucleus test, chromosome aberration test
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- other: aqueous solution
- Details on test material:
- - Name of test material (as cited in study report): Quinine hydrochloride- other: obtained from Merck, Darmstadt, Germany
Constituent 1
Test animals
- Species:
- hamster, Chinese
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Age at study initiation: 8-13 weeks- Weight at study initiation: 30 +- 2 gENVIRONMENTAL CONDITIONS- Temperature (°C): 21 +-1 °C- Humidity (%): 55 +- 5 %- Air changes (per hr): 15- Photoperiod (hrs dark / hrs light): 12 h
Administration / exposure
- Route of administration:
- oral: gavage
- Frequency of treatment:
- A single Quinine hydrochloride treatment was given 2 h after BrdU implantation.
Doses / concentrations
- Remarks:
- Doses / Concentrations:110 mg Quinine hydrochloride / kg body weightBasis:actual ingested
- No. of animals per sex per dose:
- sister chromatid exchange test: 4 animals (2 male, 2 females)micronucleus test: 6 animals (3 male, 3 females)chromosome aberration test: 6 animals (3 male, 3 females)
- Control animals:
- yes
- Positive control(s):
- alkylating agent cyclophosphamide (10 mg/kg i.p.) obtained from ASTA Pharmaceuticals, Bielefeld, F.R.G.
Examinations
- Tissues and cell types examined:
- 1000 polychromatic erythrocytes/animal were evaluated for micronuclei and 300 metaphases/animal were scored for structural aberrations. In the sister chromatid exchange 50 metaphases/animal were evaluated.
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negativeThe results of three cytogenetic test in Chinese hamsters were negative. Thus, quinine hydrochloride can be considered not genotoxic.
- Executive summary:
The genotoxicity of quinine hydrochloride was determined with the sister chromatid exchange test, micronucleus test and chromosome aberration test. The cytogenetic tests were performed with doses up to 110 mg quinine hydrochloride/kg body weight. The results of three cytogenetic test in Chinese hamsters were negative. Quinine hydrochloride is not genotoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.