Registration Dossier
Registration Dossier
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EC number: 807-426-3 | CAS number: 1438383-89-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 9-bromo-3-(2-bromoacetyl)-8,9,10,11-tetrahydro-5H-6-oxatetraphen-8-one
- EC Number:
- 807-426-3
- Cas Number:
- 1438383-89-1
- Molecular formula:
- C19H14Br2O3
- IUPAC Name:
- 9-bromo-3-(2-bromoacetyl)-8,9,10,11-tetrahydro-5H-6-oxatetraphen-8-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- All animals used were allowed to acclimatise to the laboratory conditions for at least 5 days.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- cotton seed oil
- Details on oral exposure:
- The test item was suspended with the vehicle aqua ad injectioem(sterile water) at a concentration of 0.2 g/mL and administered at a dose volume of 10 mL/kg.
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 3
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived until the end of the study without showing any test-item related signs of toxicity.
- Gross pathology:
- At necropsy, no macroscopic findings were observed in any animal of both steps.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- On the basis of the test results the substance should be not classified .
LD50 cut-off (rat): unclassified
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