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Diss Factsheets
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EC number: 284-660-7 | CAS number: 84961-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Sema. 1988. Manual of tests for assessing chemical agents toxicity, 1 ed. Brasilia: MHU.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Benzene, mono-C12-14-alkyl derivs., fractionation bottoms
- EC Number:
- 271-073-6
- EC Name:
- Benzene, mono-C12-14-alkyl derivs., fractionation bottoms
- Cas Number:
- 68515-32-2
- IUPAC Name:
- 271-073-6
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 241-267 g males, 180-208 g females
- Housing: conventional breeding station
- Diet (e.g. ad libitum): available
- Water (e.g. ad libitum): available
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 35-53 cm2 males; 33-42 cm2 females
- % coverage: less than 10% of body surface
- Type of wrap if used: Elizabethan collars were placed on animals to prevent ingestion of test substance.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hrs
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 ml
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hrs
- Doses:
- 0, 3600 (males), or 4300 mg/kg (females)
- No. of animals per sex per dose:
- Five of each sex per dose were tested.
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were made daily, body weights were taken every 7 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 4 300 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 600 mg/kg bw
- Mortality:
- No animals died during the study.
- Clinical signs:
- other: No adverse clinical signs were seen during the study.
- Gross pathology:
- No abnormal pathological finding were noted.
- Other findings:
- Doses up to 4300 mg/kg did not cause death or produce clinical, behavioral, or anatomical alterations in female rats. Doses up to 3600 mg/kg bw did not produce adverse effects in male rats.
Any other information on results incl. tables
Average Body Weight Gain (g)
Control |
3600 mg/kg bw (males) 4300 mg/kg bw (females) |
|
Males |
17.2 |
33.0 |
Females |
12.4 |
13.4 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 in female rats was > 4300 mg/kg bw, and in male rats was > 3600 mg/kg bw.
- Executive summary:
This study examined the acute dermal toxicity of heavy alkylates. Groups of 5 male and 5 female rats were exposed to concentrations of 0, 3600 (males), and 4300 mg/kg bw (females) dermally. Animals were observed for the next 14 days for mortality and clinical signs. Animals were weighed every 7 days. At the end of the study, animals were necropsied. No animals died during the study, and no adverse clinical signed were noted. Body weight gains of treated animals were also comparable to controls. The acute dermal LD50 for both female rats was > 4300 mg/kg bw, and male rats was > 3600 mg/kg bw.
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