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Diss Factsheets
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EC number: 202-804-9 | CAS number: 99-96-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- study period 4 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: pilot study, non-GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
- Principles of method if other than guideline:
- The purpose of the study was to evaluate the effect of 4-HBA to immature female mice when administered by subcutaneous injection for 3 consecutive days. This study is a dose-setting study for a subsequent uterotrophic assay in immature mice.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-hydroxybenzoic acid
- EC Number:
- 202-804-9
- EC Name:
- 4-hydroxybenzoic acid
- Cas Number:
- 99-96-7
- Molecular formula:
- C7H6O3
- IUPAC Name:
- 4-hydroxybenzoic acid
- Details on test material:
- preformulated test substance was delivered to the lab.
The details listed below refer to the test substance, not the formulated product:
- Name of test material (as cited in study report): 4-hydroxybenzoic acid
- Source: NIPA Laboratories
- Batch reference number: 4110J082
- Purity: 99.52%
- Colour: white
- Physical state: Powder
- Expiry: 11/07/2001
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Alpk:CD-1 mouse (19-20 days old, 12-14g on receipt) supplied by Rodent Breeding Unit, Alderley Park, Macclesfield, Cheshire, U.K.
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- arachis oil
- Duration of treatment / exposure:
- 3 injections on 3 consecutive days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5, 5.0, 50.0, 100.0 mg/kg bw.
- No. of animals per sex per dose:
- 2
- Details on study design:
- Two female mice in each group were dosed once daily, by subcutaneous injection, for 3 consecutive days, with a dose volume of 5.0 ml/kg bw..
Examinations
- Observations and examinations performed and frequency:
- Clinical observations and bodyweight were recorded daily.
- Sacrifice and pathology:
- The animals were killed by an overdose of anaesthetic followed by exsanguination. No further examination.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- No effects on body weight and body weight gain (no control group)
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- >= 100 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Subcutaneous Doses up to and including 100.0 mg/ kg bw. dissolved in 5.0 ml/kg bw. arachis oil were tolerated without effects on body weight and without clinical signs.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Subcutaneous Doses up to and including 100.0 mg/ kg bw. dissolved in 5.0 ml/kg bw. arachis oil were tolerated without effects on body weight and without clinical signs.
Applicant's summary and conclusion
- Conclusions:
- Subcutaneous Doses up to and including 100.0 mg/ kg bw. dissolved in 5.0 ml/kg bw. arachis oil were tolerated without effects on body weight and without clinical signs.
- Executive summary:
Groups of 2 immature female Alpk:CD-1 mice (19-20 days old) received a single subcutaneous injection of 0.5, 5.0, 50,0, 100.0 mg/kg bodyweight of 4-HBA once a day for 3 consecutive days.
Subcutaneous Doses up to and including 100.0 mg/ kg bw. dissolved in 5.0 ml/kg bw. arachis oil were tolerated without effects on body weight and without clinical signs after administration to female immature CD-1 mice.
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