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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 203-560-6 | CAS number: 108-20-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- -Observed for up to 7 days after dosing
- Principles of method if other than guideline:
- 16 solvents administered orally (via syringe) to newborn, immature, young adult, and older adult rats. LD50 values were calculated by the method of Litchfield and Wilcoxon (1949).
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP requirements.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Isopropyl ether
- Physical state: Liquid
- Analytical purity: Commercial solvents, analytical grade
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Four different ages were tested - 24 to 48-hour old (newborn rats); 14-day old (immature rats); age not reported for young adults and older adults.
- Weight at study initiation: 5 to 8 g (newborn rats); 16 to 50 g (immature rats); 80 to 160 g (young adults); 300 to 470 g (older adults).
- Fasting period before study: Non-fasted rats were used.
Administration / exposure
- Route of administration:
- other: Orally via straight needle or microsyringe
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: Not reported
- Doses:
- Not reported
- No. of animals per sex per dose:
- -6 to 12 mixed sex animals per study in newborn and immature 14-day old rats
-6 male animals per study on young and older adults - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: No - Statistics:
- The LD50 and associated confidence limits were calculated both by the method of Litchfield and Wilcoxon (1949) and by a probit analysis statistical program via an IBM-1800 calculator. Parallel probit analyses (Finney, 1952), programmed for the IBM-1800 computer, were carried out on the LD50 values to compare the potencies within the 3 to 4 age groups for each of the solvents tested.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6.4 mL/kg bw
- 95% CL:
- 4.7 - 8.6
- Remarks on result:
- other: 14-day old
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 16.5 mL/kg bw
- 95% CL:
- 15.3 - 17.7
- Remarks on result:
- other: young adult
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 16 mL/kg bw
- 95% CL:
- 14.1 - 18.4
- Remarks on result:
- other: older adult
- Mortality:
- No information available
- Clinical signs:
- other: No information available
- Gross pathology:
- No information available
- Other findings:
- - Other observations: Able to obtain only a rough approximation of the acute oral LD50 values for newborn rats due to minimum administration volumes (generally < 1 mL/kg body weight).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)
- Conclusions:
- Based on a di-isoproply ether density of 723 g/L:
LD50 (male/female 14-day old) = 4600 mg/kg bw
LD50 (male young adult) = 12000 mg/kg bw
LD50 (male older adult) = 11900 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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