Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-858-8 | CAS number: 75-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 values for IPC in Danio rerio, based on the initial concentrations of the test article were reported to be: LC50 (72 hrs) = 159.9 mg/L and (96 hrs) = 159.9 mg/L. Corrected LC50 based on the calculated average effective concentration of ca. 60% of the initial test article concentration and 10% mortality rate in the vehicle control; 72 h LC50 = 113.8 mg/L, 96 h LC50 = 113.8 mg/L.
Danio rerio (reported as Brachydanio rerio): LC50 (72 and 96 hours) = 189.7 mg/L (from nominal concentrations) or 113.8 mg/L (from 60% of nominal concentrations)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 113.8 mg/L
Additional information
One acute toxicity study was performed to assess the acute toxicity of IPC to the freshwater fish species Danio rerio (reported as Brachydanio rerio) (Thun, 1990). The study was conducted under GLP and according to OECD Guideline 203; however, the body weights of the test animals were not reported. The study also followed the EEC Directive 79/831 Annex V guidelines. The study was conducted in a semi-static system, and the test substance was replenished every 24 hours on the basis that IPC is volatile. In their calculation of the LC50 values, the authors appear not to have taken into account the 10% mortality that occurred in the vehicle control group (10% Tween 80) at 48, 72 and 96 hours. When the 10% mortality in the vehicle control is considered, the LC0 values increase in the following manner: 48 hr LC0 = 260 mg/L (nominal) or 156 mg/L (60% of the nominal concentration); 72 hr LC0 = 100 mg/L (nominal) or 60 mg/L (60% of the nominal concentration); 96 hr LC0 = 100 mg/L (nominal) or 60 mg/L (60% of the nominal concentration). Furthermore, the alternative interpretation of the LC0 values increases the calculated LC50 values to the following: 72 and 96 hr LC50 = 189.7 mg/L (from nominal concentrations) or 113.8 mg/L (from 60% of nominal concentrations).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.