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EC number: 245-205-8 | CAS number: 22766-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC of ≥ 14.2 mg/L (OECD 301B)
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of 2-octyldodecyl
myristate (CAS 22766-83-2) to activated sludge microorganisms are
available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a
read-across to the structurally related source substance 2-octyldodecyl
isooctadecanoate (CAS 93803-87-3) was conducted. The source substance is
representative to evaluate the short-term toxicity of the target
substance to fish. The target substance is characterised as an ester of
C18 iso branched fatty acid esterified with 2-octyldodecan-1-ol. The
source substance is structurally very similar to the target substance.
2-octyldodecyl isooctadecanoate (CAS 93803-87-3) is characterised by a
longer fatty acid chain length (C18 iso branched) and by the same
alcohol component (2-octyldodecan-1-ol).This read-across is justified in
detail in the overall summary (IUCLID Section 6.1) and within the
analogue justification in IUCLID Section 13. In this case of
read-across, the best suited (highest degree of structural similarity,
nearest physico-chemical properties) read-across substance was used for
the assessment.
Since no studies on the toxicity to aquatic microorganisms are available
a ready biodegradability study from the source substance is used to
derive a NOEC for the toxicity to aquatic microorganisms. If a compound
degrades well in a ready biodegradability test, or does not inhibit the
degradation of a positive control at a certain concentration, this
concentration can be used as a NOEC value. This approach is in
accordance with the Guidance on information requirements and chemical
safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA,
2012). A substance can be assumed to be not inhibitory to aquatic
microorganisms, if in the toxicity control of a ready biodegradation
test, more than 25% degradation based on CO2 evolution occurred within
14 days (OECD guideline 301). For the source substance 2-octyldodecyl
isooctadecanoate (CAS 93803-87-3) a biodegradation test conducted
according to OECD guideline 301B is available (Desmares-Koopmans, 1998).
The test includes a toxicity control, which contains 14.2 mg/L of the
test substance and 39.85 mg/L of the reference material. The toxicity
control attained 78.1% degradation after 14 days of incubation. Hence,
the substance is not toxic to aquatic microorganisms and a NOEC of ≥
14.2 mg/L was derived.Based on the available results from a structurally
related read-across substance (in accordance to Regulation (EC) No
1907/2006 Annex XI, 1.5) which is characterised by a comparable
structure, it can be concluded that 2-octyldodecyl myristate will not
exhibit effects on activated sludge microorganisms and does not inhibit
the microbiological process of degradation in sewage treatment plants.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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