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Diss Factsheets
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EC number: 218-463-4 | CAS number: 2156-97-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was conducted according to an internal BASF method. Several groups of 5-10 mice per sex and dose were treated intraperitoneally with preparations of the test substance in aqueous emulsion with traganth.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-Propenoic acid, C12-14-alkyl esters
- EC Number:
- 282-516-8
- EC Name:
- 2-Propenoic acid, C12-14-alkyl esters
- Cas Number:
- 84238-60-8
- Molecular formula:
- Unspecified
- IUPAC Name:
- 2-Propenoic acid, C12-14-alkyl esters
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Tuebinger
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: BASF AG
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous emulsion with traganth
- Doses:
- 1.6, 0.8, 0.4, 0.2, 0.1, and 0.05 mL/kg bw (corresponding to 1392, 696, 348, 174, 87, and 43.5 mg/kg bw)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Group-wise documentation of clinical signs was performed over the 14-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. Upon completion of the study, all animals were sacrificed and submitted to gross-pathological examination.
- Statistics:
- On the basis of the observed lethality, the LD50 value was estimated using a graphical evaluation of the dose response curve on probability paper.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Exposure time: 336 hour(s)
- Mortality:
- The number of late deaths was noteworthy. Most deaths occurred between the first and the sixth day of the study. Then, on the tenth day after administration of the test compound another four animals died. The surviving animals recovered during the observation period between day 7 and 12.
- Clinical signs:
- The animals of the two highest dose groups showed at the day of administration stagger, ataxia, tonic muscle flaccidity, and in some animals also sedation. The other animals were only calmer than usual. On the following days, apathy, stagger, piloerection and in part adhering eye lids were observed.
- Gross pathology:
- Gross-pathological examination of the animals which had died during the course of the study and of the animals sacrificed at the end of the experiment revealed intraperitoneal adhesions and agglutinations. 11 abscesses in the abdominal wall and one liver abscess were found.
Any other information on results incl. tables
Mortality:
Dose Cumulative mortality after
[mg/kg bw] 1 h 24 h 48 h 7 d 14 d
-----------------------------------------------------------
1392 0/10 1/10 1/10 10/10 10/10
696 0/10 1/10 2/10 6/10 7/10
348 0/10 0/10 0/10 0/10 0/10
174 0/20 0/20 0/20 0/20 1/20
87 0/20 0/20 0/20 0/20 1/20
43.5 0/10 0/10 0/10 0/10 1/10
-----------------------------------------------------------
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.