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EC number: 224-169-7 | CAS number: 4223-03-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Skin penetration has been shown to be extremely low ca. 0.3% in rats and lower than this with human skin. Based on the recovery of ca.90% from the study using none labeled test substance a worst case absorption could be considered to be 10%. In the absence of any data on oral and inhalation exposure, these are both assumed to be 100%. No specific metabolism data are available, only information from the OECD Toolbox.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 0.3
- Absorption rate - inhalation (%):
- 100
Additional information
The in-vitro skin penetration data indicates a very low /slow penetration for human skin of significantly less than the rat skin which showed 0.3% in 24 hours. We have no information on absorption via the gastrointestinal tract or via the lungs after inhalation, therefore the ECHA defaults are quoted of 50% absorption via the gastrointestinal tract and 100% absorption in the lungs after inhalation.
CAS 4223-03-4 has no data in the QSAR (OECD) Toolbox.
For the evaluation the structure was considered to be: C(=O)(C=C)NC(C)(C)CC(C)(C)C
The various metabolism/transformations:
No information from observed metabolism.
Simulators:
- Autoxidation: 0 metabolites
- Dissociation: : 0 metabolites
- Hydrolysis: (acidic & basic conditions) yes, forming of the branched C8-amine and acrylic acid
- Skin metabolism: 2 metabolites: being the two hydrolysis products
- Rat liver S9 metabolism: 7 metabolites. (See: OECD Toolbox - chemicals list S9-simulator.pdf) (For it looks like various possible oxidations, including one epoxide from the acrylic part)
Otherwise, being an acrylic acid compound, one can expect the various messages regarding possible protein and DNA reactivity in the profile. However the lack of evidence for genotoxicty or skin sensitization does not indicate any significant reaction with proteins or DAN that results in any toxic effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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