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EC number: 231-915-5 | CAS number: 7778-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
With potassium sulphate a reliable acute dermal toxicity study in rats (according to OECD 402) has been performed showing an LD50 > 2000 mg/kgbw. A reliable acute oral toxicity study with rats according to OECD 425 with potassium magnesium sulphate has been performed, showing LD50>2000 mg/kg bw. An inhalation study with ammonium sulphate investigating mucociliary clearance did not show effects in rats at 3.6 mg/m3.
Based on reliable studies on potassium magnesium sulphate and ammonium sulphate for acute oral route, the LD50 for the sulphate category is >2000 mg/kg. Based on a reliable acute inhalation study on ammonium sulphate, the LC50 for the sulphate category is >1200 mg/m3.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 1 200 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
No reliable acute oral toxicity study is available for potassium sulphate. However, several second source publications show a high oral LD50 value for potassium sulphate. This is confirmed by reliable acute oral toxicity studies performed in rats according to OECD 425 with potassium magnesium sulphate (and ammonium phosphate sulphate) (LD50 > 2000 mg/kg bw).
For acute dermal toxicity a reliable OECD 402, EC B.3, EPA and JMAFF guideline study in rats with potassium sulphate itself is available, showing an LD50>2000 mg/kg bw. No mortality, effects on body weight and gross pathology were observed. However, some effects on the skin were: Chromodacryorrhoea was noted in two males and one female on Day 1. Scales and scabs were noted in one male and one female between Day 5 and 11.
Therefore, acute toxicity studies with two possible routes of exposure are available and thus no acute inhalation study is required. In addition, the vapour pressure is assumed to be very low and for the granules and the powder of the substance, hardly any/limited number of particles are present that are inhalable (<100 micrometer) (see particle size distribution). However, mucociliary clearance was investigated with ammonium sulphate and appeared not to have been significantly affected in male rats exposed to 3.6 mg/m³ (0.4 µm) for 4 h. In addition, the acute inhalation toxicity of ammonium sulfate aerosols (average diameter 1 - 3 µm) is very low with 8-h LC50 values of greater than 900 mg/m³ for guinea pigs. Rats were exposed repeatedly for 8 h/d to 1000 - 1200 mg/m³ (average diameter 2 - 3 µm) without mortality. No specific signs of toxicity were reported from these studies.
Justification for classification or non-classification
Studies show that potassium sulphate does not have to be classified for acute toxicity according to Directive 67/548/EC and the CLP Directive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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