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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 926-099-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- The full waiving argumentation is detailled in the document "Skin sensitization: waiving argumentation" in the box below.
The studies mentionned as weight of evidence are detailled in the endpoints of the section 7.10.4 (sensitisation data, human) - the pdf printed version of these endpoints is also enclosed in the box below.
No data for the target substance (Note Q man-made vitreous fibres) are available. Thus, data from appropriate read-across substances (mineral wool fibres and fibreglass) were used to assess the potential for skin sensitisation. An in vitro or in vivo skin sensitisation study does not need to be conducted because historical human data on skin sensitisation from 4 studies are available (see IUCLID sections 7.10.4) and were assessed in a weight-of-evidence approach. Human data provide evidence to indicate no concern of skin sensitising potential of mineral wool fibres and fibreglass after exposure. In particular, the study from Jolanki et al., (2002) reported only a very low incidence of allergic contact dermatitis possibly attributable to occupational exposure to stone/rock wool in Finnish workers (2 out of 11,532 cases with occupational dermatoses recorded during 1990-1999), which was considered not statistically significant. The other 3 studies showed that the reported skin effects (e.g. after patch test performance) by mineral wool fibres and fibreglass were of mechanical and not of allergic nature (Björnberg & Löwhagen, 1977; Possick et al., 1970; Wang et al., 1993), which supports the conclusion that mineral wool fibres and fibreglass do not act as skin sensitisers.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- The testing for skin sensitisation is waived, because MMVF note Q fibres are inorganic fibres, whose physicochemical properties suggest a low potential to cross biological membranes and consequently a low potential to penetrate the skin. Skin penetration is prerequisite in the LLNA test. It is evaluated that MMVF note Q fibres will not give any response in the LNNA test. Furthermore, many years of workers exposure has not revealed cases of skin sensitisation. It is assessed that MMVF note Q fibres are not a skin sensitiser in humans.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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