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Diss Factsheets
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EC number: 930-915-9 | CAS number: 1318-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral
In the two reliable studies neither mortality nor any signs of clinical poisoning were observed.
Inhalation
In the key study with crystalline aluminosilicate no signs of toxicity were observed up to 18.3 mg/l during the exposure or the fourteen day observation period.
In the supporting study in a type A zeolite, all of the compounds tested appeared to produce an increased incidence of pulmonary abnormalities such as areas of hemorrhage and atelectasis, but these effects were not attributed to specific substances (like type A zeolite). Further, generally their incidence was considered to be slight to moderate. At least, there was no mortality observed.
Also, as supporting information: An in-vitro alveolar macrophage assay (used for predicting the acute toxicity of nanomaterials) showed that the effects of the four types of zeolites were heterogeneous and comparatively low when compared to natural aluminosilicates such as bentonite or kaolin studied with the same experimental setup (s.a. IUCLID 7.9.4)
Dermal
In the only reliable study neither mortality nor any signs of clinical poisoning were observed.
Key value for chemical safety assessment
Additional information
Four synthetic zeolites were tested for their in vitro bioactivity with the well establish NR8383 alveolar macrophage test.
Overall, the effects of the four types of zeolites were heterogeneous and comparatively low when compared to natural aluminosilicates such as bentonite or kaolin studied with the same experimental setup. The microscopically visible fractions of all four synthetic zeolites were completely ingested by the macrophages.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.