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EC number: 200-901-0 | CAS number: 75-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to microorganisms: 3 hr EC10 >100 mg/l (OECD 209), read-across from a structurally-related substance, trimethoxy(methyl)silane.
Key value for chemical safety assessment
Additional information
There are no microorganism toxicity data available for dichloro(dimethyl)silane (CAS 75 -78 -5), therefore good quality data for the structurally-related substance, trimethoxy(methyl)silane (CAS 1185 -55 -3), have been read across. Both substances have structurally similar silanol hydrolysis products, dimethylsilanediol and methylsilanetriol, respectively. The other hydrolysis products are hydrogen chloride and methanol, respectively.
Methanol does not have adverse effects on microorganisms (OECD, 2004).
Hydrogen chloride is not expected to have adverse effects on microorganisms in a sewage treatment plant, where the pH is maintained within a favourable range.
Dichloro(dimethyl)silane and trimethoxy(methyl)silane are within an analogue group of substances within which, in general, there is no evidence of significant toxicity to microorganisms.
This analogue group for the toxicity to microorganisms endpoint consists of a number of sub-classes of substances
(based on structure/functionality)
with different main codes (used to represent the different sub-classes). However, read-across is carried out between substances with the same main code in most cases.
The table below presents microorganism toxicity data available for substances within the sub-class I-2 of
Alkoxysilanes, silanols, acetoxysilanes and chlorosilanes, etc, where the Si part is of low-biological reactivity, once any hydrolysis is accounted for.
Dichloro(dimethyl)silane and trimethoxy(methyl)silane are members of this sub-class.
It is therefore considered valid to read-across the results for trimethoxy(methyl)silane to fill the data gap for the registered substance.Additional information is given in a supporting report (PFA, 2013j) attached in Section 13 of the IUCLID 5 dossier.
Microorganism toxicity data available for substances within the relevant sub-class I-2 of chemicals
CAS |
Chemical Name (CAS Name) |
Main code |
Guideline Number |
Test method |
Species |
PFA Klimisch code |
Year |
Duration |
Result: E(I)C50 (mg/l) |
Result: NOEC (Or EC10/EC20) (mg/l) |
1066-40-6 |
Hydroxytrimethylsilane |
I-2 |
OECD 209 and ISO 1892 |
ASRI |
|
1a |
1992 |
Uncertain |
6670 |
|
31795-24-1 |
Potassium methylsilanetriolate |
I-2 |
OECD 209 |
ASRI |
|
1a |
2009 |
3 h |
|
EC10 >100 mg/l |
139147-73-2 |
Silane, dichlorodicyclopentyl- |
I-2-D-C |
OECD 209 |
ASRI |
|
1a |
1997 |
3 hr |
>100 |
|
124-70-9 |
Dichloro(methyl)(vinyl)silane |
I-2-D-C |
OECD 209 |
ASRI |
|
1a |
2009 |
3hr |
>100 mg/l |
|
126990-35-0 |
Dicyclopentyldimethoxysilane |
I-2-D-Me-M |
OECD 209/EU C11/Huls AG method (WOE) |
ASRI/ASRI/oxygen consumptionP. putida |
|
1a/1a/2c |
1996 |
3 hr |
>water solubility |
|
1000-50-6 |
Butylchlorodimethylsilane |
I-2-M-C |
88/302/EC |
ASRI |
|
1a |
1996 |
3h |
>340 |
|
13154-25-1 |
Chlorotri(3-methyl-propyl)silane |
I-2-M-C |
OECD 209 |
ASRI |
|
2b |
|
3 hr |
>1000 (nominal, parent) |
100 (nominal, parent) |
5894-60-0 |
Trichloro(hexadecyl)silane |
I-2-T-C |
OECD 209 |
ASRI |
|
1a |
|
3h |
>1000 |
≥1000 mg/l |
75-94-5 |
Trichloro(vinyl)silane |
I-2-T-C |
OECD 209 |
ASRI |
|
1a |
2009 |
3hr |
>100 mg/l |
|
1185-55-3 |
Trimethoxy(methyl)silane |
I-2-T-Et-H |
OECD 209 |
ASRI |
|
1a |
2009 |
3hr |
>100 mg/l |
EC10 >100 mg/l |
17980-47-1 |
Triethoxyisobutylsilane |
I-2-T-Et-H |
OECD 209 |
ASRI |
|
1a |
|
3h |
>1000mg/l |
≥1000 mg/l |
2943-75-1 |
Triethoxyoctylsilane |
I-2-T-Et-M |
OECD 209 |
ASRI |
|
1a |
|
3 hr |
>1000 |
≥1000 mg/l |
16068-37-4 |
4,4,7,7-tetraethoxy-3,8-dioxa-4,7-disiladecane |
I-2-T-Et-M |
DIN 38 412, Part 8 (Pseudomonas cell multiplication inhibition test) |
growth inhibition test |
P. putida |
1c |
1994 |
16 h |
>8000 mg/l |
8000 mg/l |
35435-21-3 |
Triethoxy(2,4,4-trimethylpentyl)silane |
I-2-T-Et-M |
OECD 209 |
ASRI |
|
1a |
2009 |
3hr |
>100 mg/l |
|
87135-01-1 |
1,6-Bis(trimethoxysilyl)hexane |
I-2-T-Me-H |
OECD 209 |
ASRI |
|
1a |
2009 |
3h |
>1000 mg/l |
|
16415-12-6 |
Hexadecyltrimethoxysilane |
I-2-T-Me-H |
OECD 209 |
ASRI |
|
1a |
|
3 hr |
>1000 |
|
142877-45-0 |
Silane, trimethoxy(1,1,2-trimethylpropyl)- |
I-2-T-Me-S |
OECD 209 |
ASRI |
|
1a |
|
3 hr |
>1000 |
≥1000 mg/l |
In the study with trimethoxy(methyl)silane (CAS 1185 -55 -3), an activated sludge respiration inhibition 3h EC10value of >100 mg/l was reported.
The study is considered to be reliability 1 (reliable without restrictions); the read across of the result is considered to be reliability 2 (reliable with restrictions). References: OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1. PFA, 2013j, Peter Fisk Associates, STP Microorganism toxicity Main Analogue Group report, PFA.300.003.006
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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