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EC number: 232-051-1 | CAS number: 7784-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a 12-month dietary feeding study conducted with the read-across substance Cryolite (trisodium hexafluoroaluminate), LOAEL values of 95 and 105 mg/kg body weight/day (the low-dose) were derived for male and female dogs, respectively (Tompkins, 1992). No other oral studies were identified.
The key 28-day inhalation study was a GLP rat study conducted according to OECD testing guideline 412, in which a NOAEC of 7 mg/m3 (the mid-dose) was identified (Muijser and Junker, 2006). The key subchronic study was a 5-month study in rats that tested aluminum fluoride at a concentration equivalent to 0.41 mg aluminum/m3; however, limited details on experimental methods and results were presented (ATSDR, 2008).
Dermal exposure is not considered the most relevant route of exposure; no dermal studies were identified.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 95 mg/kg bw/day
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 7 mg/m³
Additional information
Information regarding the speciation of both the registered substance, aluminium fluoride (AlF3), and a read-across substance, cryolite, was sourced from a literature article reporting computer-aided QSAR estimates of the speciation of the substances in aqueous media utilizing SOLGASWATER (version Win SGW) model. The author tabulated the expected Al(III) speciation at pH 7.2 and an ionic strength of 0.15, intended to represent a physiological medium, for additions of AlF3 and of cryolite of 0.001 mM, 0.1 mM and 10 mM. At 0.001 mM, both substances gave identical distributions of only hydroxy-Al species, at 0.1 mM both substances gave very similar distributions of predominantly hydroxy- and hydrox-fluoro-Al species, and at 10 mM both substances gave very similar distributions of predominantly hydroxy-fluoro- and fluoro-Al species. On the basis that exposure to the registered substance, AlF3, or to the read-across substance, cryolite, is expected to generate very similar proportions of essentially the same aluminium complexes within the solubility range of AlF3, cryolite is considered to be an appropriate surrogate for AlF3.
A single oral study was identified (Tompkins, 1992); this study was similar in design to OECD testing guideline 452. The read-across substance Cryolite was administered in the diet to Beagle dogs for a period of 12 months. Dietary levels were 0, 3000, 10000, or 30000 ppm, equivalent to 0, 95, 366, or 1137 mg/kg body weight/day for males and 0, 105, 387, or 1139 mg/kg body weight/day for females. Four (4) animals per sex were included in each group. Endpoints assessed included clinical signs, body weight and body weight gain, haematology, clinical chemistry, and microscopic examinations. The LOAEL was reported to be 3000 ppm (equivalent to 95 and 105 mg/kg body weight/day in males and females, respectively), based on increases in emesis, nucleated cells in males, renal lesions, and a decrease in urine specific gravity in females.
The key 28-day inhalation study was that of Muijser and Junker (2006). This GLP study was conducted according to OECD testing guideline 412. Male and female Wistar rats (5/sex/dose) were exposed by nose-only inhalation to aluminum trifluoride at concentrations of 0, 1, 7, or 50 mg/m3. Exposures were conducted for 6 hours/day, 5 days/week for 4 weeks. A full examination was conducted with the exception of detailed clinical observations, ophthalmoscopy, and urinalysis. A NOAEC of 7 mg/m3was reported, based on observations in the high-dose group that included increased absolute and relative lung weights (males and females), increased absolute and relative liver weights (males), changes in tracheobronchial lymph nodes, and other lung inflammatory changes.
The key subchronic inhalation study was a 5-month study in rats that was summarized by a secondary source (ATSDR, 2008). In this study, Sprague-Dawley rats were exposed to aluminum fluoride for 6 hours/day, 5 days/week for 5 months. The concentration of aluminum fluoride was reported to result in exposure to 0.41 mg aluminum/m3; no other information on the exposure conditions was reported. Lungs were observed for alveolar damage and body and brain weights were examined (further details not provided). Suggestive evidence of alveolar macrophage damage was observed following the 5-month exposure; increases in lysozyme levels were observed in the lavage fluid. No body weight effects were observed. No brain weight effects were observed although tissues were not examined histologically.
Justification for classification or non-classification
The available in vivo repeated dose studies on both the notifiable substance and an acceptable surrogate did not identify any toxicologically significant changes in the test animals. Thus, the data are conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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