Registration Dossier
Registration Dossier
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EC number: 202-615-1 | CAS number: 97-88-1
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although only a short communication, a dermatological standard method has been reported
Data source
Reference
- Reference Type:
- publication
- Title:
- Butyl methacrylate monomer and ethyl methacrylate - frequency of reaction
- Author:
- Maibach H, Hjorth N, Fregert S et al.
- Year:
- 1 978
- Bibliographic source:
- Contact Derm, 4: 60
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- survey
- Principles of method if other than guideline:
- 542 dermatitis patients were tested with 1% n-butyl methacrylate in petrolatum
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyl methacrylate
- EC Number:
- 202-615-1
- EC Name:
- Butyl methacrylate
- Cas Number:
- 97-88-1
- Molecular formula:
- C8H14O2
- IUPAC Name:
- butyl methacrylate
Constituent 1
Method
- Type of population:
- other: patients with dermatitis
- Subjects:
- - Number of subjects exposed: 542
- Sex: no data
- Age: no data
- Race: no data
- Demographic information: no data - Clinical history:
- - History of allergy or casuistics for study subject or populations: contact dermatitis
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: A1-Test or Finn chamber
- Description of patch:
- Vehicle / solvent: petrolatum
- Concentrations: 1%
- Volume applied: no data
- Testing/scoring schedule: 48 h and96 h
- Removal of test substance: no data
EXAMINATIONS
- Grading/Scoring system: ICDRG scale
- Statistical analysis: no data
Results and discussion
- Results of examinations:
- 1/542 patients reacted to butyl methacrylate (1% in petroleum)
Applicant's summary and conclusion
- Conclusions:
- 1/542 patients reacted to butyl methacrylate (1% in petroleum). Past history of dermatitis and use of acrylic paints was proposed as being of relevance.
- Executive summary:
5421 patients with dermatitis were patch-tested for allergic reactions. 1 patient reacted to butyl methacrylate (1% in petroleum). Past history of dermatitis and use of acrylic paints was proposed as being of relevance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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