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Diss Factsheets
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EC number: 200-871-9 | CAS number: 75-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Arcton 22
- IUPAC Name:
- Arcton 22
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- C57BL
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- C57BL/6JfCD-1/Alpk
Administration / exposure
- Route of administration:
- inhalation: vapour
- Details on exposure:
- Mice were exposed to vapor concentrations
of 0 (5 mice/sex), 50,000 (5 mice/sex) or 150,000 ppm (15 mice/sex) for 6
hours in a dynamic air-flow chamber. - Duration of treatment / exposure:
- 6 hours
- No. of animals per sex per dose:
- 0 (5 mice/sex), 50,000 (5 mice/sex) or 150,000 ppm (15 mice/sex)
- Positive control(s):
- no data
Examinations
- Tissues and cell types examined:
- Mice were sacrificed and bone marrow
was examined for micronucleated polychromatic erythrocytes at 24 hours
after treatment with 50,000 ppm, and 24, 48, or 72 hours after treatment
with 150,000 ppm. - Details of tissue and slide preparation:
- no data
- Evaluation criteria:
- examination of micronucleated polychromatic erythrocytes
- Statistics:
- no data
Results and discussion
- Additional information on results:
- The frequency of micronucleated polychromatic
erythrocytes did not increase in any of the treatment groups, indicating
that Arcton 22 was not clastogenic in mice under the conditions of this
assay.
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: not clastogenic
- Executive summary:
In a test for
clastogenicity mice were exposed to vapor concentrations of 0 (5 mice/sex), 50,000 (5 mice/sex) or 150,000 ppm (15 mice/sex) for 6 hours in a dynamic air-flow chamber. The frequency of micronucleated polychromatic erythrocytes did not increase in any of the treatment groups.So it was considered that Arcton 22 was not clastogenic in mice under test conditions.
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