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EC number: 202-095-6 | CAS number: 91-76-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to OECD guideline study with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 6-phenyl-1,3,5-triazine-2,4-diyldiamine
- EC Number:
- 202-095-6
- EC Name:
- 6-phenyl-1,3,5-triazine-2,4-diyldiamine
- Cas Number:
- 91-76-9
- Molecular formula:
- C9H9N5
- IUPAC Name:
- 6-phenyl-1,3,5-triazine-2,4-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- head only
- Vehicle:
- other: clean dry filtered compressed air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Single chamber concentration (exposure-dose): 0.687, 1.400, 2.489, 3.365 mg/L by inhalation head only.
the corresponding nominal concentration: 2.726, 6.464, 13.947, 20.167 mg/L - No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- A similiar group of 10 rats (5 male and 5 female) was exposed to filtered air as a control
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 2.932 mg/L air
- 95% CL:
- > 2.346 - < 4.504
- Exp. duration:
- 4 h
- Mortality:
- All animals were examined twice daily to detect any which were dead or moribund. Moribund animals were removed and necropsied for human reasons and to prevent autolysis.
- Clinical signs:
- other: The animals were observed at hourly intervals during the exposure period, then for the remainder of the working day, and once daily thereafter for 14 days.
- Body weight:
- The body weight of each animal was recorded immediately before and after exposure, on days 8 and 15 of the study and the necropsy.
- Gross pathology:
- The following procedure were applied to all animals killed at the end of the study and to those killed in extremis.
Necropsy:
A full internal and external examination was made under the general supervision of a pathologist. The nasal passages were examined and an assessment made of any irritation of the respiratory tract.
Organ weights:
The lungs, bronchi and trachea of the animal were dissected free from fat and other contiguous tissue and weighed together.
Histology:
Sample of all gross lesion were fixed in 10% buffered formalin and retained without further processing.
Any other information on results incl. tables
STATISTICAL RESULT:
-death: Deaths occurred in male and female groups at levels of 2.489 mg/L and above. Overall there was a dose-related relationship between mortality and chamber concentration. All deaths occurred on days one and two of the study.
-body weight gain: Body weight losses occurred in the first week of the study in exposed groups, with a degree of recovery in the second week.
TOXIC EFFECTS:
-clinical chemistry: Marked clinical signs without any specific signs of local lung toxicity were first observed on the day of exposure. The signs included lethargy, ataxia and prostation sometimes accompanied by panting.
-histopathology: There was no treatment-related effect on lung weight in survivors, and only occational increases in lung weight in decedents.
-necroscopy: Animals surviving to termination were unremarkable macrocopically.The only changes in decedents were non-specific pulmonary changes.
Concentration(mg/L) mortality on day Mortality ratio 1 2 3-15 days 1-15
Male control 0 / 5
0.687 0 / 5
1.400 0 / 5
2.489 1 1 / 5
3.365 3 3 / 5
Female control 0 / 5
0.687 0 / 5
1.400 0 / 5
2.489 1 2 3 / 5
3.365 3 3 / 5
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Harmful if inhaled Criteria used for interpretation of results: EU
- Conclusions:
- LC50 (4 hr, rat inhalation) = 2.932 mg/L
- Executive summary:
In the acute inhalation toxicity study, groups of young adultrat, Aprague-Dawley. male/femalewere exposed by inhalation route to
6 -phenyl-1,3,5 -triazine-2,4 -diyldiamine for 4 hours to head only at concentrations of 0.687, 1.400, 2.489, 3.365 mg/L. Animals then were observed for 14days.
LC50Combined = 2.932 mg/L (95% C.I. 2.346 to 4.504)
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