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Diss Factsheets
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EC number: 238-874-2 | CAS number: 14806-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1996-06-28 to 1996-09-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is the result of a structural analogue substance used as read-across substance. Study is conducted according to Guidelines in a GLP certified laboratory.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Toxic Substance Control Act (TSCA), 40 CFR, Part 798, Subpart A, General Toxicity Testing, Acute Dermal Toxicity, 798, 1100.
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Self-certified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 427-360-5
- EC Name:
- -
- IUPAC Name:
- 427-360-5
- Details on test material:
- Description: Pale yellow solid
Stability of test compound: Stable
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test animals –
Age at start of adaptation: 10 to 12 weeks
Weight at dosing: At least 2.0-3.0 kilograms
Source: Animals were purchased from a registered commercial breeder.
Acclimatisation period: At least 5 days
Diet: Comercial Rabbit Ration ad libitum.
Water: Tap water ad libitum.
Housing: Individually housed
Environmental conditions -
Temperature: 63 - 73°F
Relative humidity: 30% - 70%
Air changes: 10 - 15 cycles/hour
Photoperiod: 12 hours light/dark cycle.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Animals were selected for the study by clipping the skin of the trunk free of hair approximately 24 hours before application of the test substance. The site of application was not abraded intentionally nor accidentally during preparation. The test substance was introduced under gauze patches two single layers thick and applied directly to the skin of the body surface (approximately 10%) of each of the ten animals. Animals were immobilized and the patches were secured in place by wrapping the entire trunk of the animal with an impervious bandaging.
- Duration of exposure:
- 24 hours
- Doses:
- A limit test was at a dose level of 2 g/kg
- No. of animals per sex per dose:
- 10 rabbits, 5 male and 5 female
- Control animals:
- not required
- Details on study design:
- 24 hrs prior to application, 5 male and 5 female rabbits were clipped on the small area (10% of the total body surface area) of the dorsal lumbar region. The test substanc was applied to the test site at a single dose level of 2000 mg/kg bw. A gauze patch was placed over the treated areas. An occlusive dressing (elastic tape) was wrapped around the trunk of the animal to avoid any ingestion of the test article. The dressings were removed 24 hrs later and any excess test material was removed by gentle washing with water.
Animals were observed daily for 14 days for mortality and clinical signs. - Statistics:
- Not applicable as no animals died during the course of this study
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: A complete LD50 was not required.
- Mortality:
- No animals died during the course of the study.
- Clinical signs:
- other: No signs of systemic toxicity were evident during the course of the study.
- Gross pathology:
- No signs of toxicity were noted at necropsy in any of the animals.
Any other information on results incl. tables
Table 1: Individual body weights
Animal no. |
Sex |
Body weight (g) |
Weight Change |
||
Day 0 |
Day 7 |
Day 14 |
|||
1 |
Male |
2.66 |
2.94 |
3.00 |
0.34 |
2 |
Female |
2.39 |
2.67 |
2.90 |
0.51 |
3 |
Male |
2.38 |
2.59 |
2.81 |
0.43 |
4 |
Female |
2.32 |
2.67 |
2.84 |
0.52 |
5 |
Male |
2.50 |
2.78 |
2.85 |
0.35 |
|
Mean ± SD |
2.45 ± 0.03 |
2.73 ± 0.13 |
2.88 ± 0.07 |
|
6 |
Female |
2.36 |
2.64 |
2.79 |
0.43 |
7 |
Male |
2.38 |
2.66 |
2.81 |
0.43 |
8 |
Female |
2.40 |
2.61 |
2.88 |
0.48 |
9 |
Male |
2.52 |
2.80 |
2.89 |
0.37 |
10 |
Female |
2.25 |
2.53 |
2.59 |
0.34 |
|
Mean ± SD |
2.38 ± 0.10 |
2.65 ± 0.10 |
2.79 ± 0.12 |
|
Table 2: Draize Scale Skin Reactions
Erythema/Oedema |
||
Animal no. |
Sex |
Day 1 |
1 |
Male |
0/0 |
2 |
Female |
0/0 |
3 |
Male |
0/0 |
4 |
Female |
0/0 |
5 |
Male |
0/0 |
6 |
Female |
0/0 |
7 |
Male |
0/0 |
8 |
Female |
0/0 |
9 |
Male |
0/0 |
10 |
Female |
0/0 |
0: No erythema/No oedema
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- No mortalities were reported in rabbits after a single dermal administration of 2000 mg/kg bw. The acute dermal median lethal dose (LD50) of RA2 was established to be greater than the limit test dose of 2000 mg/kg bw.
Under the conditions of this test and in accordance with provisions of the Global harmonised System of Classification and Labelling of Chemicals (GHS), 2-Propanol, 1', 1" -Nitrilotris-, Acetate (Salt) does not warrant any classification on the basis of its acute dermal toxicity. - Executive summary:
The Read Across test substance RA2 was evaluated for its potential to produce systemic toxicity or death following a single topical 24 hour application to the skin of albino rabbits.
No mortalities, clinical signs or alterations in body weight were seen throughout the course of this study.
Based on the results of this study, the median lethal dose of RA2 to rabbits in an acute dermal toxicity study is greater than 2000 mg/kg bw.
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