Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-150-7 | CAS number: 7440-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-12-12 to 2008-12-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline-compliant study under GLP without deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Beryllium
- EC Number:
- 231-150-7
- EC Name:
- Beryllium
- Cas Number:
- 7440-41-7
- Molecular formula:
- Be
- IUPAC Name:
- beryllium
- Details on test material:
- - Name of test material (as cited in study report): Beryllium Metal Powder
- Molecular formula (if other than submission substance): Be
- Substance type: Metal
- Physical state: Solid
- Analytical purity: 99.4%
- Lot/batch No.: O-30H grade /Blend # 051106
- Expiration date of the lot/batch: 2050-12-31
- Storage condition of test material: at room temperature protected from light
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS Young Adult New Zealand White, SPF
- Source: Harlan Laboratories, Horst, The Netherlands
- Age at study initiation: 18 weeks (male), 17 weeks (females)
- Weight at study initiation: 2550 g (male), 2223-2455 g (females)
- Housing: individually in steel cages with haysticks
- Diet (e.g. ad libitum): pelleted standard rabbit diet ad lib., Provimi Kliba, Kaiseraugst, Switzerland
- Water (e.g. ad libitum): community tap water ad lib.
- Acclimation :under laboratory conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 30-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 g beryllium metal powder
- Duration of treatment / exposure:
- test material was not washed out after instillation
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 (1 male, 2 females)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM:according to the numerical scoring system listed in the Council
Regulation (EC) No 440/2008, B.5
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: average 7d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24h
- Irritant / corrosive response data:
- No corrosion of the cornea was observed at any of the reading times.
- Other effects:
- No staining produced by the test item of the treated eye was observed. Grey test item remnants were evident in all animals at the 1-hour reading. No abnormal findings were observed in the cornea or iris of any animal at any of the measurement intervals.
Slight to moderate reddening of the conjunctivae was noted in all animals at the 1-hour reading and persisted as slight up to 72 hours after treatment. Slight swelling (chemosis) of the conjunctivae was observed in all animals at the 1-hour reading. Slight to moderate reddening of the sclerae was present in all animals 1 hour after treatment and persisted as slight in two animals up to the 24- or 72-hour reading. Slight to moderate ocular discharge was recorded in all animals at the 1-hour reading.
No abnormal findings were observed in the treated eye of any animal 7 days after treatment, the end of the observation period for all animals.
Any other information on results incl. tables
Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point / Reversibility |
Cornea |
Iris |
Conjunctivae |
Chemosis |
Max. score: 4 |
Max. score: 2 |
Max. score: 3 |
Max. score: 4 |
|
60 min |
0/0/0 |
0/0/0 |
2/1/1 |
1/1/1 |
24 h |
0/0/0 |
0/0/0 |
1/1/1 |
0/0/0 |
48 h |
0/0/0 |
0/0/0 |
1/1/1 |
0/0/0 |
72 h |
0/0/0 |
0/0/0 |
1/1/1 |
0/0/0 |
Average 24 h, 48 h, 72 h |
0 |
0 |
1 |
0 |
7 days |
0/0/0 |
0/0/0 |
0/0/0 |
0/0/0 |
Reversibility*) |
|
|
c |
c |
Average time for reversion |
|
|
7 d |
24 h |
*) Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Beryllium metal powder was not irritaing to rabbit eyes.
- Executive summary:
The eye irritation potential of beryllium metal powder was investigated according to OECD guideline 405. 0.1 g of the unchanged test item were applied into the conjunctival sac of the left eye of three New Zealand White rabbits. The test item was not washed out. The eyes of the animals were observed for signs of irritancy 1, 24, 48 and 72 h after adminitstration. Slight initial swelling was observed after 1 hour, but resolved by 24 hours. Redness of the conjunctivae was observed until 72 h after administration, and thus animals were observed again after 7 days, by when the redness had completely resolved in all animals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.