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EC number: 203-943-8 | CAS number: 112-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: reproduction/development
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 09/1994-02/1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to the OECD and it is GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 421 (Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- Dodecyldimethylamine
- EC Number:
- 203-943-8
- EC Name:
- Dodecyldimethylamine
- Cas Number:
- 112-18-5
- Molecular formula:
- C14H31N
- IUPAC Name:
- dodecyldimethylamine
- Details on test material:
- - Physical state: clear liquid
- Storage: at room temperature
- Stability: stable for the duration of the study
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test species: Rat/Sprague-Dawley Crl
Source: Charles River Deutschlanf GmbH
Animals: Five groups of 10 male and 10 female rats each
Body weight: males: 313-340g and female: 216-242g
Age: 69-72 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil, DAB 10
- Details on exposure:
- Administration volume: 2 mL/kg b.w. /day
Dose-levels: Group 1: control (vehicle), Group 2: 50mg, Group 3: 150mg, Group: 300mg, Group:450mg (10 males / 10 females) - Details on mating procedure:
- Mating was monogamous: 1 male and 1 female animal were placed together in one cage during the dark period.
Each morning the female were examined for the presence of sperm. If findings were negative, mating was repeated. - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- Males: 14 days prior to mating and during the 14-day mating period
Female: 14 days prior to mating and during the mating period, pregnancy and lactation period. - Frequency of treatment:
- administered orally at a constant volume of 2 mL/kg b.w/dya on 7 days per week during the following periods:
males: two weeks orior to mating period and approx. 2 weeks post mating at least until the minimum total dosing period of 28 days had been completed.
females: throughout the study beginning two weeks prior to mating and continuing uo to, and including, day 3 post partum or the day before sacrifice. - Details on study schedule:
- 1 adaptation week and approx. 54 test days [14 days premating, (up to) 14 days mating, 22 days gestation. 4 days lactation]
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 150, 300 and 450 mg/kg b.w./day
Basis:
nominal conc.
- No. of animals per sex per dose:
- control, low dose, low intermediate dose, high intermediate dose and hich dose [ 10 males / 10 females] for all doses
- Control animals:
- yes
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Sex:
- male/female
- Remarks on result:
- other: Generation not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Under the present test conditions the no-observed-effect level (NOEL) for both parent animals and their pups was 50 mg Dodecyldimethylamine / kg b.w./day, by gavage in a reproduction / devolopment toxicity screening test with rats.
150 mg/kg b.w./day were in the beginning lethal range for pregnant rats and in the toxic range for embryos/fetuses/pups.
Only one dam of the group treated with 300 mg/kg b.w./day delivered one female pup alive.
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