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Diss Factsheets
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EC number: 231-209-7 | CAS number: 7446-81-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Feb - 23 Feb 1961
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: BASF test using an internal method, as the study was conducted before the implementation of GLP and OECD guideline 404 (1981).
- Short description of test conditions: White Vienna rabbits were used. 2 animals were treated for 1, 5 and 15 minutes and 4 other animals for 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the test substance solved in aqua dest. (30 % for 20 h and 50 % for 1, 5, 15 min and 20 h) on a patch. After the application time of 1, 5, and 15 minutes, respectively, the skin was first washed with undiluted Lutrol 9, then with an aqueous Lutrol solution (50 %). The skin of the animals that had been treated with the test substance dermally for 20 hours, remained unwashed. In addition, skin tissue from the ear was tested by wrapping the ear with a cotton patch drenched in approx. 2 mL of the test compound. These results from the ear, however, were not taken into account for evaluation as they do not represent testing of the dorsal / lateral flank of the back.
- Parameters analysed / observed: The animals were observed for 8 days and skin reactions were recorded on working days. The report describes findings after 24 hours and at the end of the observation period. Thus, for final evaluation, the findings after 48 and 72 hours from the raw data were taken into account. - GLP compliance:
- no
Test material
- Reference substance name:
- Sodium acrylate
- EC Number:
- 231-209-7
- EC Name:
- Sodium acrylate
- Cas Number:
- 7446-81-3
- Molecular formula:
- C3H3NaO2
- IUPAC Name:
- sodium acrylate
- Details on test material:
- - Name of test material (as cited in study report): Sodium acrylate
- Physical state: solid
- Analytical purity: no data
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: not specified
- Purity: not specified
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.77 kg (mean)
ENVIRONMENTAL CONDITIONS: no details reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no amount specified
- Concentration (if solution): 30 % (20 h exposure), 50 % (1, 5, 15 min, and 20 h exposure) - Duration of treatment / exposure:
- 1 min, 5 min, 15 min, and 20 h
- Observation period:
- 48 - 72 hrs
- Number of animals:
- 2 animals (1, 5, 15 min); 4 animals (20 h)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: patch, no further data
REMOVAL OF TEST SUBSTANCE
- Washing: yes (exposure 1, 5, 15 min) first with undiluted Lutrol 9, then with an aqueous Lutrol solution (50 %); no (exposure 20 h)
- Time after start of exposure: 1, 5, and 15 min, respectively
OBSERVATION TIME POINTS: after 24, 48, 72 hours; 8 days
SCORING SYSTEM:
The original BASF grading was converted into the numerical grading according to the OECD Draize system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 20 hrs exp. (50 % aqueous)
- Basis:
- mean
- Remarks:
- 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0.59
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hrs
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 20 hrs exp. (50 % aqueous)
- Basis:
- mean
- Remarks:
- 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Table 1: Mean erythema score after 24, 48 and 72 h
Exposure time | Concentration [%] | 24 h | 48 h | 72 h | mean | ||||
|
| Animal 1 | Animal 2 | Animal 1 | Animal 2 | Animal 1 | Animal 2 | Animal 1 | Animal 2 |
1 min | 50 | 0 | 0 | 0 | 0 | -* | -* | 0 | 0 |
5 min | 50 | 0 | 0 | 0 | 0 | -* | -* | 0 | 0 |
15 min | 50 | 0 | 0 | 0 | 0 | -* | -* | 0 | 0 |
20 h | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
20 h | 50 | 1** | 1 | 0 | 1 | -* | 0 | 0.5 | 0.67 |
* The study was discontinued after 48 hrs.
** blotchy
Table 2: Mean edema score after 24, 48 and 72 h
Exposure time | Concentration [%] | 24 h | 48 h | 72 h | mean | ||||
|
| Animal 1 | Animal 2 | Animal 1 | Animal 2 | Animal 1 | Animal 2 | Animal 1 | Animal 2 |
1 min | 50 | 0 | 0 | 0 | 0 | -* | -* | 0 | 0 |
5 min | 50 | 0 | 0 | 0 | 0 | -* | -* | 0 | 0 |
15 min | 50 | 0 | 0 | 0 | 0 | -* | -* | 0 | 0 |
20 h | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
20 h | 50 | 0 | 0 | 0 | 0 | -* | 0 | 0 | 0 |
* The study was discontinued after 48 hrs.
Tabe 3: Findings at test termination
Exposure time | Concentration [%] | Skin findings | |
|
| Animal 1 | Animal 2 |
1 min | 50 | no skin findings | no skin findings |
5 min | 50 | no skin findings | no skin findings |
15 min | 50 | no skin findings | no skin findings |
20 h | 30 | no skin findings | no skin findings |
20 h | 50 | no skin findings | no skin findings |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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