Registration Dossier
Registration Dossier
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EC number: 202-626-1 | CAS number: 98-00-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The predicted 48 hour invertebrate QSAR EC50 was 223.76 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 223.76 mg/L
Additional information
The test duration in the available toxicity study was too short (24 hours instead of 48 hours). The EC50 from this study based on impared mobility was 328 mg/L.
The USEPA EPIWEB 4.0 QSAR software was used to calculate an invertebrate 48 hour EC50. Within the software the ECOSAR module contains a library of QSARs for predicting aquatic toxicity. ECOSAR Version 1.00 has the potential to identify over 120 chemical classes and calculates QSARs for numerous endpoints and organisms. The QSARs in ECOSAR for both neutral organics and classes are based on a linear mathematical relationship between the predicted log Kow values and the corresponding log of the measured toxicity values (mmol/L) for the training set chemicals within each chemical class of interest. Specific Furfuryl Alcohol phy-chem parameters were used when running ECOSAR and included the measured log Kow for the substance. The results from ECOSAR indicated that furfuryl alcohol’s toxicity was best represented by the benzyl alcohol chemical class. The phys-chem properties of both substances were then analysed to ensure that this was indeed the case. The phys-chem data for Furfuryl Alcohol (FA) show that the substance falls within the domains (limitations) of the ECOSAR software and therefore the calculated QSARs should be Klimisch scored as 2 (reliable with restrictions). It must also be noted that a representative chemical class was found for FA in the software database and this provides additional support for the use of the QSAR. Finally, an experimental result for a shorter exposure period also indicates that EC50 values would be greater than 100 mg/L and therefore support the use of the QSAR.
The predicted 48 hour invertebrate QSAR LC50 was 223.76 mg/L.
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