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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 403 (1981)
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Dastib 845
- IUPAC Name:
- Dastib 845
- Details on test material:
- Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
Produkt ist wachsartiges festes material: Mittlere
Teilchengrosse ist nicht definiert.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Acclimatization period: 5 days
temperature: 22±2°C
humidity: 60-70%
12 h light regime
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: Fur das Produkt wurde kein aerodynamischer Durchmesser benutzt, da es sich um einen wachsartigen Feststoff handelt. For the product was not used aerodynamic diameter, since it is a waxy solid.
- Details on inhalation exposure:
- Gesamter KÈrper
Duration of exposure for control / test groups: 7 h
Air-flow through the chember for control/ test groups: 11 L/min.
Temperature inside the chamber for control/test groups : 28 ± 2°C
Temperature of the water bath for control/test groups: 50 ±1°C - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 7 h
- Concentrations:
- The total amount of the Dsatib found has been determined after 7 hours as 22.0 mg in the first washing bottle and 1.1 mg in the second washing bottle. The total amount of Dastib 845 passed through the inhalation chamber during an inhalation experiment has been determined as 23.1 mg, when the total volume od 4.62 m3 of air having been passed. Concentration = 0.005 mg/L.
- No. of animals per sex per dose:
- 5 males for control and a test groups
5 females for control and a test group - Control animals:
- yes
- Details on study design:
- control group: 5 males + 5 females
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.005 mg/L air
- Exp. duration:
- 7 h
- Mortality:
- Male: .005 mg/L; Number of animals: 5; Number of deaths: 0
Female: .005 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Das Aussehen und Verhalten der behandelten Tiere wurde wahrend des 14-tagigen Observierungszeitraum nicht beeinflusst. Das Korpergewicht verandert sich nicht. The appearance and behavior of the treated animals was
- Gross pathology:
- Effects on organs: Es zeigten sich keine behandlungsbezogenen Auswirkungen in
irgendeinem der Organe der Tiere, die der Prufsubstanz
ausgesetzt wurden. Eine Abnahme der somatomotorischen
Aktivitaten wurden sowohl in den Kontrollgruppen als auch
den Versuchsgruppen festgestellt. Diese Observation bezog sich auf die gesenkte Temperatur in der Versuchskammer.
There were no treatment-related effects in any of the organs of the animals that were exposed by substance. A decrease in the somatomotor activities were both in control and the test groups noted. This observation related to the reduced temperature in the test chamber.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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