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Diss Factsheets
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EC number: 200-860-9 | CAS number: 75-31-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: American Society for Testing and Materials (ASTM), Standard Test Method for Estimating Sensory Irritancy of Airborne Chemicals, Annual Book of ASTM Standards, Designation E 981-84
- Principles of method if other than guideline:
- Determination of sensory irritation potency by oronasal exposure, key parameter: RD50
(RD50 = the exposure concentration resulting in a 50-% decrease in the respiratory rate). - GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- Isopropylamine
- EC Number:
- 200-860-9
- EC Name:
- Isopropylamine
- Cas Number:
- 75-31-0
- Molecular formula:
- C3H9N
- IUPAC Name:
- propan-2-amine
- Test material form:
- liquid
- Details on test material:
- high-purity liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: OF1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: IFFA Credo, Domaine des Onciens, Saint-Germain sur l'Arbresle, France
- Age at study initiation:
- Weight at study initiation: 20 - 25 g
- Fasting period before study: unfasted
- Housing: in groups of 10
- Diet., water: ad libitum
- Acclimation period: 7 d
controlled ENVIRONMENTAL CONDITIONS (no detailed information given)
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION (see details below)
- Exposure apparatus: 200 L inhalation chamber
- Method of holding animals in test chamber: Mice were restrained in a body plethysmographs with nose-only exposure.
- Source and rate of air:
- Method of conditioning air:
- System of generating particulates/aerosols:
- Temperature, humidity, pressure in air chamber:
- Air flow rate:
- Air change rate:
- Method of particle size determination:
- Treatment of exhaust air:
TEST ATMOSPHERE
- Brief description of analytical method used: HPLC ( sampling by silica gel in glass tubes; after derivatisation resulting m-Toluene derivatives were
analysed by reversed-phase chromatography with UV detection)
- Samples taken from breathing zone: yes - Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- Exposure period: 60 min
- Frequency of treatment:
- 1x, 15 min
- Post exposure period:
- Recovery period: 30 min
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Several concentrations measured from 69 - 197 ppm
Basis:
analytical conc.
- No. of animals per sex per dose:
- 6 per test concentration
- Control animals:
- other: internal control = each test animal before exposure
- Details on study design:
- Observation period: 60 min exposure, 30 min recovery, before, during and after exposure respiratory rate was determined
Results and discussion
Any other information on results incl. tables
The RD50 value for isopropylamine was 157 ml/m3 (ppm) which corresponds to approx. 0.39 mg/L. Note: Calculation based on MW = 59 and molar volume of 24 L (20 °C): 1 ml/m3 = 2.46 mg/m3
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Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, the test substance produced sensory upper airway irritation, like related amines
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