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EC number: 241-774-1 | CAS number: 17796-82-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-(cyclohexylthio)phthalimide
- EC Number:
- 241-774-1
- EC Name:
- N-(cyclohexylthio)phthalimide
- Cas Number:
- 17796-82-6
- Molecular formula:
- C14H15NO2S
- IUPAC Name:
- N-(cyclohexylthio)phthalimide
- Details on test material:
- Batch No.: 093/06
Purity: 99.43% ( w/w)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- volume of test substance solution: 50 mL ( least 2 mL per individual)
Content of (Ca+Mg) ions in dilution water: 2.59 - 2.66mmol/L
pH of dilution water: 7.8 - 7.9
Preliminary test:
stock solution of test substance: 50.09 mg/0.5L saturated solution in dilution water determined concentration: 9.16 mg/L
saturated solution dosing: 1000, 500, 100, 50, 10 mL in 1000mL of dilution water
conductivity of distiled water: 0.153 mS/m
pH of dilution water: 7.9
Oxygen content: 7.2 mg/L at 19.9°C
content of (Ca+Mg) in dilution water: 2.66 mmol/L
Full semi-static test:
Test solution 1: Stock solution of test substance: 100.04 mg/L saturated solution in dilution water , determined concentration : 4.48 mg/L
saturated solution dosing: 1000, 870, 760, 660, 570, 500, 430 mL in 1000 mL of dilution water.
conductivity of distiled water: 0.119 mS/m
pH of dilution water: 7.9
Oxygen content: 9.0 mg/L at 19.9°C
content of (Ca+Mg) in dilution water: 2.61 mmol/L
Test solution 2 ( renewal the test solution after 24 hours): Stock solution of test substance: 100.07 mg/L saturated solution in dilution water , determined concentration : 4.25 mg/L
saturated solution dosing: 1000, 870, 760, 660, 570, 500, 430 mL in 1000 mL of dilution water.
conductivity of distiled water: 0.119 mS/m
pH of dilution water: 7.8
Oxygen content: 8.9 mg/L at 19.7°C
content of (Ca+Mg) in dilution water: 2.59 mmol/L
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Straus were obtained by aperiodic parthenogenesis from own laboratory breeding. Daphnia were fed by a mxture of algae. The sensitivity of test species is periodically monitored by testing with the reference substance, potassium dichromate. The grow-up gravid females are separeted into dilution water. Young daphnia born in 24 hours are segregated to the handling container from which they entered the experiment. At handling a care should be taken of not to penetrate the air under animals shell.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20±2°C with variation of ±1°Cat each individual test
- pH:
- pH of solutions - full semi-static test: 7.7 - 8.1
- Dissolved oxygen:
- higher than 3 mg/L
Concentration of dissolved oxygen - full semi-static test: 7.3 - 9.2 mg/L at 19.6 - 19.9°C - Details on test conditions:
- Number of test animal: 20 for each concentration and control in preliminary test
20 for each concentration and control in full semi-static test
Lighting: natural variation of daily light and dark
Without feeding, without aeration
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.46 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.21 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- < 0.82 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- < 0.82 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 1.47 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Duration:
- 48
- Dose descriptor:
- EC100
- Effect conc.:
- > 1.47 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- verification test was carried out in period from 11.12.2007 to 13.12.2007
results:
24h - EC50=1.15 mg/L (95% CL)
48h - EC50= 0.80 mg/L (95% CL)
The result of last interlaboratory test arrangment by Centre for Assessment of Laboratories of T.G.Masaryk Water Research Institute Prague in 2006 for potassium dichromate was:
48-hour EC50= 0.61 - 1.11 mg/L
The immobilisation of test species in reference substance solution expressed as EC50 fits into the accepted range in the interlaboratory tests.
Any other information on results incl. tables
Full semi-static test, Immobilisation of daphnia
Determined conc. -TWM | mg/L | 1.47 | 1.32 | 1.20 | 1.07 | 0.96 | 0.91 | 0.82 | C |
saturated solution dosing | mL/L | 1000 | 870 | 760 | 660 | 570 | 500 | 430 | C |
number of live animals | 24 h/1st series | 8 | 5 | 5 | 10 | 10 | 8 | 10 | 10 |
number of live animals | 24 h/2nd series | 5 | 4 | 9 | 7 | 10 | 10 | 9 | 10 |
number of live animals | 24 h/ total | 13 | 9 | 14 | 17 | 20 | 18 | 19 | 20 |
Immobilisation % | 24 hours | 35 | 55 | 30 | 15 | 0 | 10 | 5 | 0 |
number of live animals | 48 h/1st series | 4 | 3 | 4 | 7 | 10 | 8 | 9 | 10 |
number of live animals | 48 h/2nd series | 3 | 3 | 5 | 6 | 8 | 8 | 9 | 10 |
number of live animals | 48 hours/total | 7 | 6 | 9 | 13 | 18 | 16 | 18 | 20 |
Immobilisation % | 48 hours | 65 | 70 | 55 | 35 | 10 | 20 | 10 | 0 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- except point 5
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