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Diss Factsheets
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EC number: 217-168-8 | CAS number: 1761-71-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish life cycle toxicity
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted calculation method
- Principles of method if other than guideline:
- Estimation of a chronic NOEC according to the acute to chronic ratio approach (ACR; ECETOC, 2003, Technical Report No. 91)
- GLP compliance:
- no
- Test organisms (species):
- other: freshwater fish
- Water media type:
- freshwater
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 1 mg/L
- Basis for effect:
- other: expected NOEC based on ACR approach
- Validity criteria fulfilled:
- yes
- Conclusions:
- The calculation based on acute fish toxicity study determines the NOEC for fish to be >1 mg/L .
- Executive summary:
The substance does not have a potential to bioaccumulate nor is it considered as a PBT/vPvB substance. The results from short-term toxicity tests on fish, Daphnia and algae demonstrate that invertebrates are the most sensitive trophic level tested. Further, a reproduction test on Daphnia magna is available (read-across to the structurally similar substance DMDC, CAS 6864-37-5). The ACR approach for fish indicated that the long-term NOEC would be greater than 1 mg/L. Therefore, it can be concluded that results from a long-term test in fish would not reveal a greater hazard than already determined by the available data. Based on the estimated long-term toxicity values (ACR approach) and for reasons of animal welfare long-term aquatic toxicity testing on fish is not indicated. Moreover, the exposure levels estimated in all relevant scenarios do not exceed the appropriate PNEC so that the risk to the environment can be considered to be adequately controlled throughout the lifecycle of the substance.
Reference
Acute/Chronic ratio approach:
Source | Description | ACR (90 %-ile) | expected NOEC (mg/L): LC50 (> 100 mg/L) / ACR |
Table 40 | all species (geometric mean) | 71 | > 1 |
Table 40 | all fish (geometric mean) | 57 | > 1 |
Table 41 | all species (individual species) | 71.2 | > 1 |
Table 41 | all fish (individual species) | 70.1 | > 1 |
Table 42 | mode of action (individual species): narcotic | 11.5 | (> 1)* |
Table 44 | fish (Pimephales promelas) | 70 | > 1 |
Table 45b | Pimephales promelas /organics | 39 | > 1 |
* not applicable for primary amines
- short term toxicity test on fish LC50 (96 h) mg/L: > 100 mg/L (neutralised)
- conclusion: table 40 -45b: expected NOEC: > 1 mg/L; approach applicable
Description of key information
There is no experimental data available.
An ACR approach for fish indicated that the long-term NOEC would be greater than 1 mg/L.
Key value for chemical safety assessment
Additional information
There is no experimental data available.
The chemical safety assessment does not indicate a need to investigate further long-term toxicity on fish. The exposure levels estimated in all relevant scenarios do not exceed the appropriate PNEC, and the likelihood and severity of an event occurring due to the physicochemical properties of the substance in the aquatic environment are negligible. Furthermore, the substance does not have a potential to bioaccumulate. In addition, the ACR approach for fish indicated that the long-term NOEC would be greater than 1 mg/L. Therefore, it may be concluded that results from a long-term test in fish would not reveal a greater hazard than already determined by the available data. Therefore, and for reasons of animal welfare long-term aquatic toxicity testing on fish is not indicated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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