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Diss Factsheets
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EC number: 203-896-3 | CAS number: 111-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Followed appropriate guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- Data scored according to the method of Draize, Woodard and Calvery (Journal of Pharm. and Exp. Therapeutics, Volume 82, Decemeber, 1944)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Adiponitrile
- EC Number:
- 203-896-3
- EC Name:
- Adiponitrile
- Cas Number:
- 111-69-3
- Molecular formula:
- C6H8N2
- IUPAC Name:
- hexanedinitrile
- Details on test material:
- - Name of test material (as cited in study report): Refined Adiponitrile
- Lot/batch No.: 957
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Undiluted compound was applied
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 168 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: skin
- Type of wrap if used: plastic strips
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 hours
SCORING SYSTEM: according to the method of Draize, Woodard and Calvery.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 0
- Basis:
- mean
- Remarks:
- All animals received a score of zero throughout the observation period
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- all animals received a score of zero
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Animal-sex | 1 hour | 24 hours | 48 hours | 72 hours | 120 hours | 168 hours |
1 - male | 0 | 0 | 0 | 0 | 0 | 0 |
2 - female | 0 | 0 | 0 | 0 | 0 | 0 |
3 - male | 0 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The data are scored according to the method of Draize, Woodard and Calvery. The compound was classed as non-irritating when applied to the intact skin of male and female rabbits. No erthema or edema developed when the compound was applied undiluted for twenty-four hours. All animals received a score of zero throughout the observation period.
- Executive summary:
The undiluted compound was applied to the clipped, intact skin of albino male and female rabbits and removed after twenty-four hours. the application was covered with plastic strips to retard evaporation and avoid contamination.
Observations were made over a period of several days for irritation.
The data, scored according to the method of Draize, Woodard and Calvery (Journal of Pharm. and Exp. Therapeutics, Volume 82, December, 1944) are shown.
The compound was classed as non-irritating when applied undiluted to intact skin of male and female rabbits.
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