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EC number: 273-749-6 | CAS number: 69012-50-6 Product of blowing smelted nickel ore in a converter to lower the iron content.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across from oral route based on bioelution data
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Acute inhalation toxicity potential of the UVCB substance was determined by reading across from the results of an acute oral toxicity study and information on gastric and alveolar bioaccessibility, resulting in an inhaled acute toxicity estimate.
- GLP compliance:
- no
- Test type:
- other: calculation using existing data
- Limit test:
- no
Test material
- Reference substance name:
- Matte, nickel
- EC Number:
- 273-749-6
- EC Name:
- Matte, nickel
- Cas Number:
- 69012-50-6
- Molecular formula:
- Not applicable
- IUPAC Name:
- Nickel matte
- Details on test material:
- Compositions Tested:
Nickel Sulphidic Matte with Copper >8% (including Cobalt 0.1 -<1%)
Nickel Sulphidic Matte with Copper >8% (including Cobalt ≥1 - <3%)
Nickel Sulphidic Matte (including Cobalt 0.1 -<1%)
Nickel Sulphidic Matte (including Cobalt ≥1 - <3%)
Nickel Metallic Matte (including Cobalt 0.1 -<1%)
Nickel Metallic Matte (including Cobalt ≥1 - <3%)
Nickel Metallic Matte (including Cobalt ≥3%)
Reasonable worst-case speciations across industry, as reported in Section 1.2.
Constituent 1
Results and discussion
Effect levels
- Dose descriptor:
- other: Acute Toxicity Estimate (ATE)
- Effect level:
- > 1 - < 5 mg/L air
- Based on:
- test mat.
- Remarks on result:
- other: prediction
Any other information on results incl. tables
The calculations were performed as follows:
Nickel Matte (sulphidic high-copper) group
>5000 mg/kg (oral LD50) X 28.2 % (gastric nickel bioelution percentage) X 30% (gastric nickel absorption) = >423 mg/kg systemically absorbed by oral route
>423 mg/kg X 0.0052 mg/L/4h (CLP extrapolation factor between inhlated and oral routes) = >2.2 mg/L/4hr
>2.2 mg/L/4h / 0.04% (alveolar nickel bioelution percentage) = > 55mg/L/4h
Thus, the oral LD50 for Nickel Matte (sulphidic high-copper) of >5000 mg/kg is equivalent to an inhalation exposure of > 55 mg/L/4h. This indicates that Nickel Matte (sulphidic high-copper) should not be classified for acute toxicity by inhalation, since the classification criteria apply to concentrations less than or equal to 5 mg/l/4hr.
Nickel Matte (sulphidic low-copper) group
>5000 mg/kg (oral LD50) X 42.5 % (gastric nickel bioelution percentage) X 30% (gastric nickel absorption) = >638 mg/kg systemically absorbed by oral route
>638 mg/kg X 0.0052 mg/L/4h (CLP extrapolation factor between inhlated and oral routes) = >3.3 mg/L/4hr
>3.3 mg/L/4h / 0.01% (alveolar nickel bioelution percentage) = > 332 mg/L/4h
Thus, the oral LD50 for Nickel Matte (sulphidic high-copper) of.>5000 mg/kg is equivalent to an inhalation exposure of > 332 mg/L/4h. This indicates that Nickel Matte (sulphidic low-copper) should not be classified for acute toxicity by inhalation, since the classification criteria apply to concentrations less than or equal to 5 mg/l/4hr.
Nickel Matte (metallic)
>5000 mg/kg (oral LD50) X 77.4 % (gastric nickel bioelution percentage) X 30% (gastric nickel absorption) = > 1161 mg/kg systemically absorbed by oral route
>1161 mg/kg X 0.0052 mg/L/4h (CLP extrapolation factor between inhlated and oral routes) = >6.0 mg/L/4hr
>6.0 mg/L/4h / 0.02% (alveolar nickel bioelution percentage) = > 301 mg/L/4h
Thus, the oral LD50 for Nickel Matte (sulphidic high-copper) of.>5000 mg/kg is equivalent to an inhalation exposure of > 301 mg/L/4h. This indicates that Nickel Matte (metallic) should not be classified for acute toxicity by inhalation, since the classification criteria apply to concentrations less than or equal to 5 mg/l/4hr.
Applicant's summary and conclusion
- Conclusions:
- According to read-across calculations based on oral toxicity and gastric and alveolar bioelution data, the substance is not classified as acutely toxic by inhalation.
- Executive summary:
As Ni matte is considered a UVCB with variable composition, the availability of reliable data on multiple samples, read-across based on bioelution data, and MeClas calculations can be combined to provide important information regarding the potential toxicity of nickel mattes. Taken together, nickel matte is not classified for acute toxicity.
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