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Diss Factsheets
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EC number: 202-464-1 | CAS number: 95-92-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to aquatic alge reveals an EC50 of 22 mg/L and an EC10 of 9.4 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 22 mg/L
- EC10 or NOEC for marine water algae:
- 9.4 mg/L
Additional information
Toxicity of Diethyl oxalate to aquatic algae was tested according to OECD test guideline 201 and GLP (BorsodChem 2011). However, the test report lacks information on preparation or stirring time of the stock solution. The obvious fluctuations show that the hydrolysis of Diethyl oxalate already started well before the test organisms were introduced and proceeded during the study period. No information can be obtained from the study to which concentrations of Diethyl oxalate and/or Oxalic acid the algae were exposed to during the course of the study. However, as outlined above, it is very likely that Oxalic acid is the relevant compound when Diethyl oxalate comes into contact with water. Though no adverse effects on Algae have been observed in the study, it therefore appears reasonable to disregard the study due to its methodological limitations. Instead, using a worst-case approach, the information available for Oxalic acid (and the second hydrolysis product, ethanol), should be used to assess the aquatic hazard of Diethyl oxalate (for more detailed information on the approach taken, please see the read-across justification attached to chapter 13 of this dossier).
Toxicity of Oxalic acid (CAS 144-62-7) to aquatic algae according to a OECD 201 guideline test reveals an ErC50 (72h) of 22.0 mg/L and NOErC (72h) of 9.4 mg/L (NITE 1998). Supportingly, Bringmann & Kuhn tested Oxalic acid in a cell multiplication inhibition test on algae during 8 d. Under this method, the onset of the inhibition of cell multiplication under the influence of hazardous water pollutants is determined and a Toxicity threshold of 80 mg/L was estimated (Bringmann & Kuhn 1978). These results are in line with the results depicted on ECHA disseminated dossier, which shows a toxicity to aquatic algae in a OECD 201 guideline test: EC50 (72h) = 20.58 mg/L and EC10 = 7.55 mg/L (ECHA disseminated dossier, accessed 13 July 2018).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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