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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2007-11-19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: According to the OECD Guideline for the Testing of Chemicals 105.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
no
Remarks:
According to ECHA Guidance (phys.chem. Studies), GLP compliance is not necessary.
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
2'-methylacetoacetanilide
EC Number:
202-267-0
EC Name:
2'-methylacetoacetanilide
Cas Number:
93-68-5
Molecular formula:
C11H13NO2
IUPAC Name:
N-(2-methylphenyl)-3-oxobutanamide
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Appearance: white, crystalline product

Results and discussion

Water solubilityopen allclose all
Water solubility:
2.7 g/L
Temp.:
20 °C
pH:
5.1
Remarks on result:
other: Equlibration time 24 h (Flask No. 1)
Water solubility:
3 g/L
Temp.:
20 °C
pH:
5.1
Remarks on result:
other: Equlibration time 48 h (Flask No. 2)
Water solubility:
2.7 g/L
Temp.:
20 °C
pH:
4.9
Remarks on result:
other: Equlibration time 72 h (Flask No. 3)
Details on results:
Mean 0,84 g/L at 20°C

Any other information on results incl. tables

Flask No.              Equlibration time at 20°C (h)       pH of aqueous solution       Test substance content (g/L)

1                                          24                                                 5,1                                          2,7

2                                          48                                                 5,1                                          3,0

3                                          72                                                 4,9                                          2,7

Mean                                   ----                                               ----                                          2,8                                                                        

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): soluble (1000-10000 mg/L)
Water solubility (20°C): 2.8 g/L
Executive summary:

The study was performed according to the OECD Guideline for the Testing of Chemicals 105.

The water solubility of Acetoacet-o-toluidide TTR is 2,8 g/L at 23°C.

A further water solubility study is published in the SIDS Dossier by the lead organization Mitsuboshi Chemical Co., Ltd. (AAOT Consortium), Japan. Method according to OECD Guideline 105.

The water solubility of the test item is 3 g/L at 25°C (pH 5.8) and therefore as interpretation of result soluble (1000 -10000 mg/L).