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EC number: 204-010-8 | CAS number: 112-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 May - 15 May 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Water hardness was not above 140 mg/L.
- GLP compliance:
- yes
- Remarks:
- According to Japanese standard
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: Test water was directly sampled by each vessel.
- Sample storage conditions before analysis: No storage before analysis. - Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Test item was mixed with HCO-20 and diluted with dilution water (concentration of stock solution: 1000 mg/L).
- Controls: Blank control and vehicle control
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): HCO-40
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): 20000 mg/L in stock solution and 100 mg/L in final test solution - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Source: Incorporated Administrative Agency, National Institute for Environmental Studies, Tsukuba, Japan
- Age at study initiation: within 24 hours
- Feeding during test: No food
ACCLIMATION
- Acclimation period: 2 weeks for parental animals
- Acclimation conditions (same as test or not): Same as test
- Type and amount of food: Chlorella vulgaris, 0.15 mgC/day
- Health during acclimation (any mortality observed): Only healthy stock was used for exposure. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 63 mg/L
- Test temperature:
- 20.4 - 20.7 °C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 8.3 - 8.6 mg/L
- Nominal and measured concentrations:
- Nominal concentration: 5 mg/L
Measured concentration: 5.02 mg/L (geometric mean during 48 hours) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL Beaker
- Material, size, headspace, fill volume: Glass, 100 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: charcoal-treated, dechlorinated and aerated tap water in Yokohama, Japan
- Alkalinity: 45 mg/L
- Ca/mg ratio: 18/4.9
- Culture medium different from test medium: Same medium
OTHER TEST CONDITIONS
- Photoperiod: 16 hours in the light, 8 hours in the dark
- Light intensity: < 1200 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
General condition and mortality were observed everyday.
TEST CONCENTRATIONS
- Range finding study: Performed twice.
- Test concentrations: (1) 0.3, 1 and 3.3 mg/L, (2) 0.5, 1 and 5 mg/L
- Results used to determine the conditions for the definitive study:
(1) Immobilization was 0% in 0.3 and 1 mg/L during 48 hours. 10% immobilization was observed in 3.3 mg/L during 24 hours and 48 hours.
(2) Immobilization was 0% in all groups in 48 hours. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- - Behavioural abnormalities: No abnormality was detected.
- Mortality of control: 0%
- Other adverse effects control: No adverse effects were detected in control. - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50: 0.23 mg/L - Validity criteria fulfilled:
- yes
Reference
Table 1. Measured concentration
Nominal Concentration (mg/L) |
Measured Concentration ,mg/L (Percent of nominal) |
||
0 Hour new |
48 Hour old |
Geometric mean |
|
Control |
< 0.3 |
< 0.3 |
- |
Solvent control |
< 0.3 |
< 0.3 |
|
5.0 |
5.16 (103) |
4.88 (98) |
5.02
|
new: freshly prepared test solutions
old: test solutions after 48 hours exposure
Table 2. The number of immobile Daphnia magna
Nominal Concentration (mg/L) |
Measured Concentration (mg/L) |
Cumulative Number of Immobilized Daphnia (Percent Immobility) |
|
24 Hours |
48 Hours |
||
Control |
Control |
0 (0) |
0 (0) |
Solvent Control |
Solvent Control |
0 (0) |
0 (0) |
5 |
5.02 |
0 (0) |
2 (10) |
Description of key information
No short-term toxicity effects up to the limit of water solubility
Key value for chemical safety assessment
Additional information
One study is available on the toxicity of docosanoic acid (CAS 112-85-6) on invertebrates.
The 48 h test provided by the Ministry of the Environment, Government of Japan (1998) was conducted according to OECD 202 and in accordance with GLP requirements. Daphnids (Daphnia magna) were exposed to 96.5% pure docosanoic acid under static conditions in a limit test by using a solvent. The EC50 (48 h) was determined to be > 5.0 mg/L based on nominal concentrations (geom.mean measured concentration: 5.02 mg/L). Thus no effects could be observed within the range of water solubility, which is determined to be 0.016 mg/L.
Based on the results of that study it can be concluded that no acute toxic effects of docosanoic acid on invertebrates are expected up to the limit of water solubility.
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