Registration Dossier
Registration Dossier
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EC number: 246-278-9 | CAS number: 24468-13-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
2-ethylhexylchloroformate was not mutagenic in the Ames test according to OECD 471.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In a reverse-mutation bacterial assay (OECD TG 471) S.typhimurium (strains TA98, TA100, TA1535 and TA1537) or E.coli(E.coliWP2) (standard plate: 0.8 - 5000 µg/plate; preincubation 0.8 - 500 µg/plate), did not show an increase in the number of revertants in either the standard plate test or the preincubation test, with or without metabolic activation. Vehicle controls and positive controls were valid. Cytotoxicity was observed at concentrations ≥ 2500 µg/plate (standard plate test) and ≥ 100 µg/plate (preincubation test). No precipitation was reported, 2-ethylhexylchloroformate was not mutagenic in this assay (BASF AG, 2000).
Justification for classification or non-classification
No classification is warranted concerning mutagenicity as classification criteria EU Regulation 1272/2008 are not met.
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