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EC number: 249-951-5 | CAS number: 29911-28-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No algal toxicity test results were available for DPnB. Endpoints were generated using QSARs to predict the acute toxicity to green algae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 519 mg/L
Additional information
A QSAR assessment of the algal toxicity of Dipropylene glycol n-butyl ether was performed. Algal toxicity was assessed in terms of the effect concentration at which growth 50% inhibition of algal growth is determined (ErC50). Prediction from two published QSARs for algal toxicity (Van Leeuwen et al. 1992 and ECOSAR 1.00 – Nabholz, V. and K. Mayo-Bean, 2008) for the unknown and 4 analogues were calculated and compared with experimental data. From this comparison it was concluded that toxicity is overestimated by ECOSAR 1.00 neutral organics module and slightly underestimated by van Leeuven et al (1992). Therefore, preference was given to a linear regression of the experimental data of three analogues (PGnPE, TPnB and PnB) against calculated log Kow using KOWWIN v 1.67 which resulted in the following relationship:
ErC50(96hr) = -1.1824.Log Kow + 1.7717 [log (mmol/l)]
The effect concentration for Dipropylene glycol n-butyl ether predicted based on this relationship is 519 mg/l. A previous QSAR is provided as supporting information. From this previous study the ECOSAR program module of EPIWIN (v0.99) predicted a Green Algae 96 -hr EC50 of 556 mg/L. The more recent QSAR is considered more reliable and conservative, therefore the EC50 value of 519 mg/L was chosen as the key endpoint.
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