Registration Dossier
Registration Dossier
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EC number: 203-571-6 | CAS number: 108-31-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study was performed complied with OECD test guideline, but it is only a summary rather than details.
Data source
Reference
- Reference Type:
- publication
- Title:
- Maleic Anhydride and Maleic Acid
- Author:
- UNEP
- Year:
- 2 005
- Bibliographic source:
- Published OECD SIDS initial assessments of HPV chemicals (2005)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Maleic anhydride
- EC Number:
- 203-571-6
- EC Name:
- Maleic anhydride
- Cas Number:
- 108-31-6
- Molecular formula:
- C4H2O3
- IUPAC Name:
- furan-2,5-dione
- Details on test material:
- purity:99.7%;
impurity:maleic acid<=0.20%;
fumaric acid<=0.01%;
benzoic acid<=0.02%;
phthalic anhydride<=0.02%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: small Russian White Rabbits
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- abraded
- Vehicle:
- other: liquid paraffin
- Controls:
- yes
- Duration of treatment / exposure:
- expose for 4 hours
- Observation period:
- 1 hour, 24 hours, 48 hours and 72 hours
- Number of animals:
- 3/sex
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 1-72 hours
- Score:
- 7.29
- Max. score:
- 8
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 8 day
- Score:
- 4
- Max. score:
- 8
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 8 day
- Score:
- 3.28
- Max. score:
- 8
- Other effects:
- No other effect found in this study.
Any other information on results incl. tables
Nothing need to be added in this field.
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- According to this study, maleic anhydride is considered to be an irritant to skin in rabbits.
- Executive summary:
Nothing need to be added in this field.
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