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Diss Factsheets
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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 25 November and 9 December 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under OECD method and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC methods for the determination of ecotoxicity, Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part C, Method C7, Abiotic degradation: hydrolysis as a function of pH; and the estimation of the soil adsorption coefficient (Koc) by HPLC
- Principles of method if other than guideline:
- The method is only applicable to water soluble substances
- GLP compliance:
- yes
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Intended use: Pharmaceutical intermediate
Appearance: White powder
Storage conditions: Room temperature
Purity: 99.4%
Date received: 2 October 1996
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No Data
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
- Details on study design:
- TEST CONDITIONS
- Test temperature: XX C
- pH: XX
- pH adjusted: yes or no
-Dilution water: HQ deionised water with conductivity of < 10 uS/cm and low carbon content (modfy as needed)
TEST SYSTEM - CHECK thse are the same
- Culturing apparatus: series of glass carboys containing 3 liters of test medium
- Number of culture flasks/concentration: 2 test flasks with test substance and inoculum
- Method used to create aerobic conditions: carbon dioxide free air
CONTROL AND BLANK SYSTEM -check these are the same
- Inoculum blank: yes
- Abiotic sterile control: yes
- Toxicity control: yes
- Other: 1 system blank, 1 procedure blank
Reference substance
- Reference substance:
- other: Sodium benzoate
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 27
- Sampling time:
- 28 d
- Details on results:
- Points of degradation plot (test substance): vv % degradation after 1 d vv % degradation after 2 d vv % degradation after 3 d vv % degradation after 6 d vv % degradation after 8 d vv % degradation after 10 d vv % degradation after 14 d vv % degradation after 16 d vv % degradation after 20 d vv % degradation after 22 d vv % degradation after 24 d vv % degradation after 27 d vv % degradation after 28 d
BOD5 / COD results
- Results with reference substance:
- Points of degradation plot (reference substance): vv % degradation after 1 d vv % degradation after 2 d vv % degradation after 3 d vv % degradation after 6 d vv % degradation after 8 d vv % degradation after 10 d vv % degradation after 14 d vv % degradation after 16 d vv % degradation after 20 d vv % degradation after 22 d vv % degradation after 24 d vv % degradation after 27 d vv % degradation after 28 d
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other:
- Conclusions:
- The test material attained vv% degradation after 28 days and therefore cannot (or can) be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline No 301B.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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