Registration Dossier
Registration Dossier
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EC number: 221-921-6 | CAS number: 3282-30-2
Endpoint summary
Administrative data
Description of key information
Additional information
The parent compound pivaloyl chloride (CAS 3282-30-2) rapidly hydrolyses in contact with water and forms pivalic acid (CAS 75-98-9) and HCl (CAS 7647-01-0). No data are available for the parent compound itself. Therefore, the toxicity assessment will mainly be based on the information available for the hydrolysis products pivalic acid and HCl.
Short-term toxicity to fish
Parent compound pivaloyl chloride: No data available
Hydrolysis product pivalic acid: BASF AG, 1999 (Key study), OECD 203, Danio rerio: 96-h LC50 = 287 mg/L (nominal, analytically verified). Based on this result, pivalic acid is with high probability acutely not harmful to fish.
Hydrolysis product HCl: MITI, 1999 (Key study), OECD 203, Cyprinus carpio: 96-h LC50 = 4.92 mg/L (acid equivalent to pH 4.3). Based on this result, HCl is considered to be acutely toxic for fish (pH dependent).
Long-term toxicity to fish
No data available.
Short-term toxicity to aquatic invertebrates
Parent compound pivaloyl chloride: No data available
Hydrolysis product pivalic acid: EG & G Bionomics, 1977 (Key study), US EPA – 660/3-75-009, Daphnia magna: 48-h EC50 = 202.9 mg/L (based on nominal test concentrations). Based on this result, pivalic acid is with high probability acutely not harmful to aquatic invertebrates.
Hydrolysis product HCl: MITI, 1999 (Key study), OECD 202, D. magna: 48-h EC50 = 0.492 mg/L (acid equivalent to pH 5.3). Based on this result, HCl is considered to be acutely very toxic for aquatic invertebrates (pH dependent).
Long-term toxicity to aquatic invertebrates
No data available.
Growth inhibition to aquatic algae
Parent compound pivaloyl chloride: No data available
Hydrolysis product pivalic acid: Exxon, 2003 (Key study), OECD 201, Raphidocelis subcapitata (previous name Pseudokirchneriella subcapitata): 72-h ErC50 = 979 mg/L, 72-h NOEC = 246 mg/L (based on analytically verified concentrations). Based on this result, pivalic acid is with high probability not harmful to aquatic algae.
Hydrolysis product HCl: MITI, 1999 (Key study), OECD 201, Raphidocelis subcapitata (previous name Pseudokirchneriella subcapitata: 72-h ErC50 = 0.492 mg/L (acid equivalent to pH 5.3), 72-h NOEC = 0.097 mg/L (acid equivalent to pH 6). Based on this result, HCl is considered to be very toxic for aquatic algae (pH dependent).
Toxicity to microorganisms
Parent compound pivaloyl chloride: No data available
Hydrolysis products pivalic acid and HCl: BASF AG, 1983 (Key study), OECD 209, industrial activated sludge: EC20 after 30 minutes of incubation >1995 mg/L (based on nominal test concentrations covering effects of the hydrolysis products pivalic acid and HCl). The inhibition of the degradation activity of activated sludge is not anticipated if introduced in appropriately low concentrations.
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