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EC number: 203-710-0 | CAS number: 109-83-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation: BASF AG, 1981. Pruefung der
Aetzwirkung von "Methylethanolamin" am Kaninchen nach 4stuendiger,
1stuendiger und 3minuetiger Einwirkungsdauer. Report No. 79/561.
Comparable to the OECD guideline 404.
Eye irritation: BASF AG, 1965. Industrial hygiene orientating
investigation. Report No. XV/126. Comparable to the OECD guideline 405.
Respiratory irritation: Ballantyne and Leung, 1996. Acute Toxicity and
Primary Irritancy of Alkylalkanolamines. Rabbits, 0.005 mL
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 May 1980 - 16 May 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets the basic scientific principles.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- BASF Test
- Principles of method if other than guideline:
- Method: BASF-Test. See further details in remarks on material and methods.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M. Gaukler, Offenbach, Germany
- Weight at study initiation: 3.5 kg (mean)
- Diet: Ssniff K, standard diet for rabbits and guinea pigs, supplied by INTERMAST GmbH, Soest, Germany, ad libitum.
- Water: tap water ad libitum. - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 3 min, 1h or 4 h
- Observation period:
- 8 days
- Number of animals:
- 4 h application: 1 male and 1 female
1 h application: 2 females
3 min appliction: 2 males - Details on study design:
- TEST SITE
- Area of exposure: 2.5x2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The test substance was removed at the end of the exposure period with Lutrol and Lutrol/water (1:1).
- Time after start of exposure: 3 min, 1 h or 4 h. - Irritation parameter:
- erythema score
- Remarks:
- ; 3 min exposure
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 1.25
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- edema score
- Remarks:
- ; 3 min exposure
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- erythema score
- Remarks:
- ; 3 min exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: 72 h reading is missing
- Remarks:
- .
- Irritation parameter:
- edema score
- Remarks:
- ; 3 min exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: 72 h reading is missing
- Remarks:
- .
- Irritation parameter:
- erythema score
- Remarks:
- ; 1 h exposure
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- edema score
- Remarks:
- ; 1 h exposure
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 2.25
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- erythema score
- Remarks:
- ; 1 h exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- edema score
- Remarks:
- ; 1 h exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: 72 h reading is missing
- Remarks:
- .
- Irritation parameter:
- erythema score
- Remarks:
- ; 4 h exposure
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- ; irreversible necrosis
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- edema score
- Remarks:
- ; 4 h exposure
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- ; irreversible necrosis
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- erythema score
- Remarks:
- ; 4 h exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: 72 h reading is missing
- Remarks:
- .
- Irritation parameter:
- edema score
- Remarks:
- ; 4 h exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: 72 h reading is missing
- Remarks:
- .
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Test substance is corrosive
- Executive summary:
Test substance is corrosive
Reference
Mean erythema score after 24 and 48 (72 h reading is missing); (animal1/animal2)
24 h | 48 h | 72 h | mean | ||
3 min | 1/2 | 1/1 | -/- | 1/1.5 | |
1 h | 4/4 | 4/4 | -/- | 4/4 | |
4 h | 4/4 | 4/4 | -/- | 4/4 |
Mean oedema score after 24 and 48 (72 h reading is missing); (animal1/animal2)
24 h | 48 h | 72 h | mean | ||
3 min | 0/2 | 0/0 | -/- | 0/1 | |
1 h | 2/3 | 2/2 | -/- | 2/2.5 | |
4 h | 3/2 | 2/2 | -/- | 2.5/2 |
3 min exposure: 24 h after application slight erythema was observed and 1 animal showed distinct edema. At the end of the observation period of 8 days the irritations eased under scaling.
1 h exposure: immediately after exposure wide spanning erythema and distinct spanning oedema were observed. After 24 h parchment-like necrosis was noted. At the end of the observation period of 8 days, persistent edema and leathery-like necrosis was observed. This is considered to be a full thickness necrosis.
4 h exposure: immediately after exposure necrosis and wide spanning oedema was noted. At the end of the observation period of 8 days irreversible necrosis was observed. This is considered to be a full thickness necrosis.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Jun 1965 - 23 Jun 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- BASF Test
- Principles of method if other than guideline:
- Method: BASF-Test. See further details in remarks on materials and methods.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.8 and 3.0 kg - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The adjacent eye served as control treated with 0.9 % NaCl (saline).
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 µL - Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 48 h reading is missing
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 48 h reading is missing
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effects
- Remarks on result:
- other: 48 h reading is missing
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Reversibility:
- other: not specified
- Remarks on result:
- other: a precise evaluation of erythema score was not possible
- Remarks:
- .
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Reversibility:
- other: not specified
- Remarks on result:
- other: a precise evaluation of erythema score was not possible
- Remarks:
- .
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The test substance is corrosive
- Executive summary:
The test substance is corrosive
Reference
Findings animal1/animal2:
Time | Opacity | Iritis | Erythema | Chemosis | |||||||
1h | 3/3 | 0/0 | x/x | 0/0 | |||||||
24h | 3/3 | 0/0 | x/x | 4/4 | |||||||
48h | -/- | -/- | -/- | -/- | |||||||
72h | 3/3 | 0/0 | x/x | 4/4 | |||||||
8d | 3/3 | 0/0 | x/x | 4/4 |
-: The 48 h reading is missing.
x: a precise evaluation of erythema score was not possible.
Mean values over 24 h and 72 h (48 h reading is missing):
Animal1: Opacity: 3; Chemosis: 4; Erythema: x; Iritis: 0
Animal2: Opacity: 3; Chemosis: 4; Erythema: x; Iritis: 0
The application of the test substance caused within 10 minutes severe corneal opacity and corrosions of the mucous membrane. After 3 days purulent exsudate was noted. At the end of the observation period of 8 days symptoms were still persistent. Severe corneal opacity is considered to be irreversible effect to ophthalmic tissue.
The original BASF grading was converted into the numerical grading according to the OECD Draize system.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
Skin irritation by MMEA has been tested in several studies.
In an irritation study (BASF, 1981), three animals were treated for 3 min, 1 h or 4 h using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance (0.5 mL). After the application time the skin was washed with Lutrol (conc.) and Lutrol/water (1:1). The animals were observed for 8 days and skin changes were recorded daily. The following outcomes were observed: 3 min exposure: 24 h after application slight erythema was observed and 1 animal showed distinct edema. At the end of the observation period of 8 days the irritations eased under scaling. 1-hour exposure: immediately after exposure wide spanning erythema and distinct spanning edema were observed. After 24 h parchment-like necrosis was noted. At the end of the observation period of 8 days, persistent edema and leathery-like necrosis was observed. This is considered to be a full thickness necrosis. 4-hour exposure: immediately after exposure necrosis and wide spanning edema was noted. At the end of the observation period of 8 days irreversible necrosis was observed. This is considered to be a full thickness necrosis.
Other dermal irritation studies confirmed these findings. MMEA was highly irritating to the skin after short dermal contact (1, 3 and 5 min) and corrosive after 15 min and longer ( BASF AG, 1966; Ballantyne and Leung, 1996).
Eye irritation
Eye irritation by MMEA has been tested in two studies. 50 µL of the test substance were applied to the conjunctival sac of one eye in 2 animals (BASF AG, 1966). The animals were observed after 10 min, 1 hour and 3 hours on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours as specified in OECD Guideline 405. The application of the test substance caused within 10 minutes severe corneal opacity and corrosions of the mucous membrane. After 3 days purulent exudate was noted. At the end of the observation period of 8 days symptoms were still persistent. Severe corneal opacity is considered to be irreversible effect to ophthalmic tissue. Ballantyne and Leung described MMEA as highly irritating to the rabbit eyes (Ballantyne and Leung, 1996). Severe eye irritating effects were produced by small volume (0.005 mL) contamination of the eye with MMEA. This agrees with that known irritating and corrosive effects on the skin. The conjunctivae became severely hyperemic and edematous within 1 hour of contaminating the eye with an associated profuse discharge. The effects remained unchanged until the end of inspection period (21 days). The cornea became moderately to severely opaque within 1 hour, affecting ¾ to the whole of the cornea. All corneas became severely opaque over the whole of their surface by 7 days and persisted as such up to the final inspection. Other effects were necrotic areas in the conjunctivae and nictitating membrane by 4hour post-application, corneal neovascularisation by 7 days and corneal ulceration by 14 days. The iris could not be inspected due to the marked keratitis.
Respiratory irritation
Based on the results of the acute toxicity and irritation studies and taken into account physical-chemical properties of MMEA (high pH value), there is sufficient reason to suppose that the test substance might exhibit a respiratory hazard. In the acute inhalation study, eye and nose discharge were observed in animals, inhaled by MMEA during 8 hours (BASF, 1965, XV/126). Ballantyne and Leung did not anticipate adverse effects from exposure to low vapour concentrations that may develop from MMEA (Ballantyne and Leung, 1996).
Justification for selection of skin irritation / corrosion endpoint: The most reliable similar to OECD 404 study Justification for selection of eye irritation endpoint: The most reliable similar to OECD 405 study
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Based in the results of the available studies, classification is warranted according to the criteria of EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulations No 1272/2008.
GHS:
- Skin Corr.1B, H314:causes severe skin burns and eye damage
- Eye Damage 1:H318:causes serious eye damage.
Furthermore that substance is classified as:
Acute toxicity - oral: Cat 4, H302:harmful if swallowed
- Acute toxicity -dermal: Cat 4, H312:harmful in contact with skin.
- STOT SE Cat.3, H335:may cause respiratory irritation, C>=5%
- Repro 2, H361 F/D: Suspected of damaging fertility or the unborn child <state specific effect if known> <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
and
- STOT RE Cat 2,H373: May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>; Affected organs: other: the kidney, testes, epidymides, ovaries, liver, and spleen).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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